Effects of Fluvastatin and Bezafibrate Combination on Plasma Fibrinogen, t-plasminogen Activator Inhibitor and C Reactive Protein Levels in Coronary Artery Disease Patients with Mixed Hyperlipidaemia (FACT Study)

M. Cortellaro; E. Cofrancesco; C. Boschetti; F. Cortellaro; M. Mancini; M. Mariani; R. Paoletti; the FACT Study Centers; on behalf of

doi:10.1055/s-0037-1613861

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2000; 83(04): 549-553
DOI: 10.1055/s-0037-1613861

Commentary

Schattauer GmbH

Effects of Fluvastatin and Bezafibrate Combination on Plasma Fibrinogen, t-plasminogen Activator Inhibitor and C Reactive Protein Levels in Coronary Artery Disease Patients with Mixed Hyperlipidaemia (FACT Study)

M. Cortellaro

¹From the University of Milan, Italy

,

E. Cofrancesco

¹From the University of Milan, Italy

,

C. Boschetti

⁴IRCCS Ospedale Maggiore, Milan, Italy

,

F. Cortellaro

¹From the University of Milan, Italy

,

M. Mancini

²Napoli, Milan, Italy

,

M. Mariani

³Pisa, Milan, Italy

,

R. Paoletti

¹From the University of Milan, Italy

,

the FACT Study Centers

› Institutsangaben

Abstract

Summary

Aim of the study

We studied the effects of fluvastatin and bezafibrate in monotherapy and in combination on plasma fibrinogen, t-plasminogen activator inhibitor (PAI-1) and C reactive protein (CRP) in patients with coronary artery disease (CAD) and mixed hyperlipidaemia

Design

In this randomised, double blind, multicentre trial 333 patients with stable angina pectoris or previous myocardial infarction or coronary revascularisation and mixed hyperlipidaemia (LDL-cholesterol 135-250 mg/dl and triglycerides (TG) 180-400 mg/dl) were randomised to fluvastatin 40 mg, bezafibrate 400 mg, fluvastatin 20 mg + bezafibrate 400 mg or fluvastatin 40 mg + bezafibrate 400 mg treatments for 24 weeks.

Result

Plasma fibrinogen significantly decreased after treatment with the combinations fluvastatin+bezafibrate (−14 and −16%) and with bezafibrate monotherapy (−9%). No significant reduction was observed after fluvastatin monotherapy (−4%). No significant changes were observed in PAI-1 and CRP plasma levels. Combination therapy significantly decreased both LDL-C and TG, and significantly increased HDL-C.

Conclusions

The combined effects on fibrinogen and plasma lipids achieved by fluvastatin and bezafibrate combination treatment might be more useful than the simple reduction of cholesterol in preventing ischaemic cardiovascular disease.

Keywords

Statin - fibrate - fibrinogen - coronary artery disease

Volltext

Referenzen

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