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Thromb Haemost 2000; 83(06): 822-825
DOI: 10.1055/s-0037-1613927
Commentary
Schattauer GmbH

Prevalence of Factor V Leiden in Patients with Myocardial Infarction and Normal Coronary Angiography

Jacques Mansourati
1   From the Cardiology Departments of Brest
,
Antoine Da Costa
2   North Hospital of Saint-Etienne
,
Stéphane Munier
1   From the Cardiology Departments of Brest
,
Bernard Mercier
3   the Human Genetics Laboratory of Brest
,
Brigitte Tardy
4   Department of Hematology, North Hospital of Saint Etienne, France
,
Claude Ferec
3   the Human Genetics Laboratory of Brest
,
Karl Isaaz
2   North Hospital of Saint-Etienne
,
Jean-Jacques Blanc
1   From the Cardiology Departments of Brest
› Author Affiliations
Further Information

Publication History

Received 08 June 1999

Accepted after resubmission 04 February 2000

Publication Date:
14 December 2017 (online)

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Summary

Factor V Leiden is associated with an increased risk of venous thrombosis and myocardial infarction in young women, but not in men in this latter case. The aim of this study was to evaluate the prevalence of this mutation in patients with myocardial infarction but normal coronary angiography.

We compared 3 groups of patients: one group consisted of 107 patients with premature myocardial infarction but no significant coronary artery stenosis; another group of 244 patients with myocardial infarction and significant coronary artery stenosis; a third group of 400 healthy controls.

Factor V Leiden was found in 13 patients (12.1%) who had a myocardial infarction without significant coronary artery stenosis, 11 patients (4.5%) who had a myocardial infarction with significant coronary artery stenosis (p = 0.01) and in 20 controls (5%) (p = 0.01). Odds ratio associated with factor V Leiden were respectively 2.93 (CI95 : 1.18-7.31) and 2.63 (CI95 : 1.19-5.78) when we compared myocardial infarction patients without significant coronary artery stenosis to controls or to patients with significant coronary artery stenosis.

In myocardial infarction patients without significant coronary artery stenosis, prevalence of factor V Leiden is significantly higher than in controls. This new finding supports the hypothesis that thrombosis plays a key role in this selected situation.

Keywords

Coagulation - myocardial infarction - thrombosis - genetics
 

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