Prothrombotic Risk Factors in Children with Acute Lymphoblastic Leukemia Treated with Delayed E. coli Asparaginase (COALL-92 and 97 Protocols)

Christine Mauz-Körholz; Ralf Junker; Ulrich Göbel; Ulrike Nowak-Göttl

doi:10.1055/s-0037-1613930

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 83(06): 840-843
DOI: 10.1055/s-0037-1613930

Commentary

Schattauer GmbH

Prothrombotic Risk Factors in Children with Acute Lymphoblastic Leukemia Treated with Delayed E. coli Asparaginase (COALL-92 and 97 Protocols)

Christine Mauz-Körholz

¹From the Department of Paediatric Haematology and Oncology, Heinrich-Heine University Medical Centre Düsseldorf

,

Ralf Junker

³Department of Clinical Chemistry and Laboratory Medicine/Institute of Arteriosclerosis Research, Westfälische-Wilhelms-University Medical Centre, Münster, Germany

,

Ulrich Göbel

¹From the Department of Paediatric Haematology and Oncology, Heinrich-Heine University Medical Centre Düsseldorf

,

Ulrike Nowak-Göttl

²Department of Paediatric Haematology and Oncology

› Author Affiliations

Abstract

Summary

Hereditary prothrombotic risk factors have been shown to increase the risk of venous thrombosis in children treated with the combination of E. coli asparaginase and steroids. In the present study the role of prothrombotic risk factors in children with ALL treated according to the COALL study protocol was investigated in 108 consecutively recruited childhood patients. The prevalence rates of prothrombotic risk factors [factor V G1691A mutation, the prothrombin G20210A variant, the TT677 methylenetetrahydrofolate reductase genotype, deficiencies of protein C, protein S, antithrombin, elevated lipoprotein (a)] in this cohort were within the range reported for healthy Caucasians, and comparable to previously reported data for other leukemic patients. Venous thromboembolism occurred in 3 of the 108 children (induction n = 1; reinduction n = 2: 2.8%), and none of these children carried a prothrombotic risk factor. The results of the present study, suggest that the role of hereditary and acquired disturbances of coagulation in the development of thromboses might depend on the treatment regimen.

Keywords

Childhood ALL - prothrombotic risk factors - symptomatic thromboembolism

Full Text

References

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