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Thromb Haemost 2000; 84(01): 54-58
DOI: 10.1055/s-0037-1613967
Commentary
Schattauer GmbH

Effect of Urinary Protein C Inhibitor on Lipopolysaccharide-induced Disseminated Intravascular Coagulation in Rats

Mitsugu Fujita
1   From the Development and Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan
,
Wakako Izutani
1   From the Development and Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan
,
Yoshikazu Komurasaki
1   From the Development and Research Laboratories, JCR Pharmaceuticals Co., Ltd., Kobe, Japan
› Author AffiliationsWe wish to thank Drs. Junichi Koga and Hiromichi Ishikawa for their comments to our study.
Further Information

Publication History

Received 13 July 1999

Accepted after resubmission 10 February 2000

Publication Date:
10 December 2017 (online)

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Summary

The effect of urinary protein C inhibitor (uPCI) on disseminated intravascular coagulation (DIC) was investigated using an experimental DIC in rats. uPCI (0.5 and 1.0 mg/kg) was continuously administrated into the left femoral vein of the rats with lipopolysaccharide (50 mg/kg)-induced DIC. In all doses, uPCI significantly prevented the drastic changes in the parameters such as fibrinogen concentration, activated partial thromboplastin time (APTT), prothrombin time (PT), fibrin/fibrinogen degradation products (FDP) level, aspartate aminotransferase (AST) level and alanine aminotransferase (ALT) level. Furthermore, uPCI significantly inhibited the increase in the levels of plasma kallikrein and thrombin which act not only as the procoagulant proteases but also as the chemotactic factors to neutrophils and monocytes. These results show that uPCI may prevent hypercoagulation, the induction of secondary fibrinolysis and organ failure in the DIC model. Therefore, uPCI may be a useful agent for the clinical treatment of DIC.

Keywords

Urinary protein C inhibitor - DIC - experimental DIC in rat
 

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