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Thromb Haemost 2000; 84(04): 571-575
DOI: 10.1055/s-0037-1614069
Review Article
Schattauer GmbH

Insulin Sensitivity and Hemostatic Factors in Clinically Healthy 58-year-old Men

Stefan Agewall
1   From the Department of Cardiology, Sahlgrenska University Hospital, Göteborg University, Sweden
,
Lena Bokemark
2   Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden
,
John Wikstrand
3   Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Göteborg University, Sweden
,
Anders Lindahl
4   Department of Clinical Chemistry, Sahlgrenska University Hospital, Göteborg University, Sweden
,
Björn Fagerberg
2   Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden
› Author Affiliations
Further Information

Publication History

Received 17 December 1999

Accepted after resubmission 05 May 2000

Publication Date:
11 December 2017 (online)

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Summary

The objective of this cross-sectional study was to investigate the relationship between factors of the coagulation- and fibrinolysis systems and insulin sensitivity in 104 clinically healthy, 58-years-old men. Insulin sensitivity (hyperinsulinemic euglycemic clamp) adjusted for lean body mass, the metabolic syndrome according to a suggested definition, and different factors in the coagulation- and fibrinolysis system were determined. Subjects with the metabolic syndrome were characterised by increases in PAI-1 activity, tPA antigen, protein C and protein S and low concentrations of tPA activity. Insulin sensitivity was independently and reversibly associated with PAI-1 (p = 0.014) and directly with tPA activity (p = 0.001). Insulin sensitivity was also significantly negatively associated with protein S and protein C and several components in the metabolic syndrome, however not remaining significant in multivariate analyses. Protein C and protein S were significantly associated with PAI-1 activity, tPA activity (negatively), tPA antigen and antithrombin III. In conclusion, the data indicated that insulin resistance and several of the clustering components in the metabolic syndrome are accompanied by increased plasma concentrations of the anticoagulatory proteins C and S which may represent a mechanism which counteracts the concomitantly occurring hypofibrinolysis.

Key words

Insulin sensitivity - plasminogen activator inhibitor activity - protein C - protein S - tissue plasminogen activator
 

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