Download PDF
Thromb Haemost 2000; 84(04): 722-723
DOI: 10.1055/s-0037-1614093
Letters to the Editor
Schattauer GmbH

The -506I/D Polymorphism of the Thrombin Receptor (PAR-1) Gene Is not Related to Myocardial Infarction in the ECTIM Study

The Etude Cas-Temoins de I’lnfarctus du Myocarde
Emmanuel Arnaud
1   From the Service d’Hématologie biologique, Hôpital Broussais, AP-HP and Unite INSERM 428, Faculte de Pharmacie, Université René Descartes, Paris
,
Odette Poirier
2   Unité INSERM 525, Paris
,
MONICA Members Group,
Martine Aiach
1   From the Service d’Hématologie biologique, Hôpital Broussais, AP-HP and Unite INSERM 428, Faculte de Pharmacie, Université René Descartes, Paris
,
Françcois Cambien
2   Unité INSERM 525, Paris
› Author Affiliations
Further Information

Publication History

Received 22 February 2000

Accepted after revision 21 April 2000

Publication Date:
11 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Lasne D, Donato J, Falet H, Rendu F. Different abilities of thrombin receptor activating peptide and thrombin to induce platelet calcium rise and full release reaction. Thromb Haemost 1995; 74: 1323-8.
    Thieme ConnectPubMedSearch in Google Scholar
  • 2 Tesfamariam B. Thrombin receptor-mediated vascular relaxation differentiated by a receptor antagonist and desensitization. Am J Physiol 1994; 267: H1962-7.
    PubMedSearch in Google Scholar
  • 3 Tesfamariam B, Allen GT, Normandin D, Antonaccio MJ. Involvement of the “tethered ligand” receptor in thrombin-induced endothelium-mediated relaxations. Am J Physiol 1993; 265: H1744-9.
    PubMedSearch in Google Scholar
  • 4 Garcia JG, Patterson C, Bahler C, Aschner J, Hart CM, English D. Thrombin receptor activating peptides induce Ca2+ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet-derived growth factor mRNA expression in cultured endothelium. J Cell Physiol 1993; 156: 541-9.
    CrossrefPubMedSearch in Google Scholar
  • 5 Garcia JG, Fenton JW, Natarajan V. Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C. protein kinase C, and cyclic adenosine 3’5’-monophosphate. Blood 1992; 79: 2056-67.
    PubMedSearch in Google Scholar
  • 6 Garcia JG, Pavalko FM, Patterson CE. Vascular endothelial cell activation and permeability responses to thrombin. Blood Coag Fibrinol 1995; 06: 609-26.
    CrossrefPubMedSearch in Google Scholar
  • 7 Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature 1991; 353: 674-7.
    CrossrefPubMedSearch in Google Scholar
  • 8 Amaud E, Nicaud V, Poirier O, Rendu F, Alhenc-Gelas M, Fiessinger JN, Emmerich J, Aiach M. Protective effect of a thrombin receptor (PAR-1) gene polymorphism towards venous thromboembolism. Arterioscler Thromb Vasc Biol 2000; 20: 585-92.
    CrossrefPubMedSearch in Google Scholar
  • 9 Schmidt VA, Vitale E, Bahou WF. Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene. J Biol Chem 1996; 271: 9307-12.
    CrossrefPubMedSearch in Google Scholar
  • 10 Li F, Baykal D, Horaist C, Yan CN, Carr BN, Rao GN, Runge MS. Cloning and identification of regulatory sequences of the human thrombin receptor gene. J Biol Chem 1996; 271: 26320-8.
    CrossrefPubMedSearch in Google Scholar
  • 11 Faisst S, Meyer S. Compilation of vertebrate-encoded transcription factors. Nucl Acid Res 1992; 20: 3-26.
    CrossrefPubMedSearch in Google Scholar