Soluble Selectins in Sepsis: Microparticle-associated, but only to a Minor Degree

• References

• 1 Kansas GS. Selectins and their ligands: current concepts and controversies. Blood 1996; 88: 3259-87.
• 2 Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Radbruch A, Hamann A. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissue. Nature 1997; 385: 81-3.
• 3 Celi A, Pellegrini G, Lorenzet R, De Blasi A, Ready N, Furie BC, Furie B. P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci USA 1994; 91: 8767-71.
• 4 Fijnheer R, Frijns CJM, Korteweg J, Rommes H, Peters JH, Sixma JJ, Nieuwenhuis HK. The origin of P-selectin as a circulating plasma protein. Thromb Haemost 1997; 77: 1081-5.
• 5 Elevated selectin levels after severe trauma: a marker for sepsis and organ failure and a potential target for immunomodulatory therapy. J Trauma 1996; 41: 653-62.
• 6 Kayal S, Jaïs JP, Aguini N, Chaudiere J, Labrousse J. Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand Factor in patients with severe infection. Am J Respir Crit Care Med 1998; 157: 776-84.
• 7 Nieuwland R, Berckmans RJ, Rotteveel-Eijkman RC, Maquelin KN, Roo-zendaal KJ, Jansen PGM, ten Have K, Eijsman L, Hack CE, Sturk A. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation 1997; 96: 3534-41.
• 8 Nieuwland R, Berckmans RJ, McGregor S, Boing AN, Romijn FPHTM, Westendorp RGJ, Hack CE, Sturk A. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood 2000; 95: 930-5.
• 9 Nomura S, Komiyama Y, Miyake T, Miyazaki Y, Kido H, Suzuki M, Kagawa H, Yanabu M, Takahashi H, Fukuhara S. Amyloid-fl protein precursor-rich platelet microparticles in thrombotic disease. Thromb Haemost 1994; 72: 519-22.
• 10 Heijnen HFG, Schiel AE, Fijnheer R, Geuze HJ, Sixma JJ. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules. Blood 1999; 94: 3791-9.