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DOI: 10.1055/s-0037-1614112
Pentoxifylline Prevents Upregulation of Monocyte Tissue Factor in Renal Transplant Recipients Undergoing Post-graft Complications
The authors thank Dr. Alain Duhamel (Laboratory of Biostatistics, CHRU of Lille) for his help in statistical analysis. This work was supported by grants from Direction de la Recherche et des Etudes Doctorales (EA 2693 and 2686), the Centre Hospitalier Regional Universitaire of Lille, and Region Nord Pas de Calais.Publikationsverlauf
Received
21. Oktober 1999
Accepted after resubmission
23. Mai 2000
Publikationsdatum:
13. Dezember 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200005/lookinside/thumbnails/10-1055-s-0037-1614112-1.jpg)
Summary
Pentoxifylline (PTX) has been demonstrated to improve graft survival in renal transplant recipients undergoing post graft complications. As activated monocytes are possible initiators of vascular damage through tissue factor (TF) expression, we evaluated the monocyte TF expression and endothelium activation markers in 140 consecutive patients receiving cadaveric kidney grafts, randomized in a double-blind study comparing PTX versus placebo. Monocyte TF expression and plasma von Willebrand factor, tissue plasminogen activator, thrombomodulin and tumor necrosis factor-α (TNF-α) levels were determined before transplantation and each month after. Additional samplings were realized in case of acute rejection. TF and TNF-α expression were significantly modified after graft. In patients with complications, PTX prevented the increase of TF expression at month one, and after rejection episodes. Endothelium activation markers were significantly modified after graft and in patients with complications but PTX had no significant effect on their plasma levels. These results suggest that the protective effect of PTX on graft survival could be related to the prevention of monocyte TF upregulation associated with complications.
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