Subscribe to RSS
DOI: 10.1055/s-0037-1614158
Compression Ultrasonography of the Leg Veins in Patients with Clinically Suspected Pulmonary Embolism
Is a More Extensive Assessment of Compressibility Useful? Financial support for this study was provided by the Dutch Health Insurance Council (nr. OG-D-94-90). HRB is an established investigator of the Dutch Heart Foundation.Publication History
Received
15 April 2000
Accepted after resubmission
19 July 2000
Publication Date:
13 December 2017 (online)
Summary
We performed a multi-center study in consecutive patients with suspected pulmonary embolism to compare the diagnostic accuracy of a two-point compression ultrasonography (only the common femoral vein and popliteal vein) with an extensive examination of compressibility (from the common femoral vein until the trifurcation of calf veins). A total of 479 patients underwent the two-point compression ultrasonography. The prevalence of pulmonary embolism was 32%. The sensitivity and specificity of this procedure were 23% (95% CI 19-26) and 98% (95% CI 96-99), respectively. Extensive compression ultrasonography was performed in 461 (96%) of these 479 patients and showed comparable accuracy indices (sensitivity 25%, 95% CI 20-28 and specificity 97%, 95% CI 95-99). We conclude that compression ultrasonography has a limited sensitivity for the detection of thrombosis in patients with acute pulmonary embolism within 24 h of presentation. A more extensive assessment of compressibility of the leg veins in these patients has no additional value as compared to the two-point assessment.
* Participating investigators are listed in the appendix, on pp. 975.
-
References
- 1 Kuijer PM, Turkstra F, van Beek EJ, ten Cate JW, Büller HR. A survey of the diagnostic and therapeutic management of patients with suspected pulmonary embolism in the Netherlands. Neth J Med 1997; 50: 261-6.
- 2 Anonymous Suspected acute pulmonary embolism: a practical approach. British Thoracic Society, Standards of Care Committee. Thorax 1997; 52 (04) 1-24.
- 3 Hull RD, Hirsh J, Carter CJ, Jay RM, Dodd PE, Ockelford PA, Coates G, Gill GJ, Turpie AG, Doyle DJ, B¸ller HR, Raskob GE. Pulmonary angiography, ventilation lung scanning, and venography for clinically suspected pulmonary embolism with abnormal perfusion lung scan. Ann Intern Med 1983; 98: 891-9.
- 4 Kruit WHJ, de Boer AC, Sing AK, van Roon F. The significance of venography in the management of patients with clinically suspected pulmonary embolism. J Intern Med 1991; 230: 333-9.
- 5 Turkstra F, Kuijer PMM, van Beek EJR, Brandjes DPM, ten Cate JW, Büller HR. Diagnostic utility of ultrasonography of leg veins in patients suspected of having pulmonary embolism. Ann Intern Med 1997; 126: 775-81.
- 6 Beecham RP, Dorfman GS, Cronan JJ, Spearman MP, Murphy TP, Scola FH. Is bilateral lower extremity compression sonography useful and costeffective in the evaluation of suspected pulmonary embolism?. Am J Radiol 1993; 161: 1289-92.
- 7 Rosen MP, Sheiman RG, Weintraub J, Mc Ardle C. Compression sonography in patients with indeterminate or low-probability lung scans: lack of usefulness in the absence of both symptoms of deep-vein thrombosis and thromboembolic risk factors. Am J Radiol 1996; 166: 285-9.
- 8 Schiff MJ, Feinberg AW, Naidich JB. Noninvasive venous examinations as a screening test for pulmonary embolism. Arch Intern Med 1987; 147: 505-7.
- 9 Christiansen F, Kellerth T, Andersson T, Ragnarsson A, Hjortevang F. Ultrasound at scintigraphic “intermediate probability of pulmonary embolism”. Acta Radiol 1996; 37: 14-7.
- 10 Smith LL, Iber C, Sirr S. Pulmonary embolism: confirmation with venous duplex US as adjunct to lungscanning. Radiology 1994; 191: 143-7.
- 11 Fournier P, Gerard F, Pottier JM, Marchal C, Pacouret G, Charbonnier B. Place des examens echographic dans le diagnostic de l’embolie pulmonaire de gravite moyenne a severe. Ann Cardio Angéiologie 1993; 42: 447-51.
- 12 Lensing AWA, Prandoni P, Brandjes DPM, Huisman PM, Vigo M, Tomasella G, Krekt J, ten Cate JW, Huisman MV, Büller HR. Detection of deepvein thrombosis by real-time B-mode ultrasonography. N Engl J Med 1989; 320: 342-5.
- 13 Cogo A, Lensing AW, Prandoni P, Hirsh J. Distribution of thrombosis in patients with symptomatic deep-vein thrombosis, implications for simplifying the diagnostic process with compression ultrasound. Arch Intern Med 1993; 153: 2777-80.
- 14 Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med 1998; 129: 997-1005.
- 15 Lensing AWA, van Beek EJR, Demers C, Tiel-van Buul MMC, Yakem-chuk V, van Dongen A, Coates G, Ginsberg JS, Hirsh J, ten Cate JW, Büller HR. Ventilation-perfusion lung scanning and the diagnosis of pulmonary embolism: improvement of observer agreement by the use of a lung segment reference chart. Thromb Haemost 1992; 68: 245-9.
- 16 Hull RD, Hirsh J, Carter CJ, Raskob GE, Gill GJ, Jay RM, Leclerc JR, David M, Coates G. Diagnostic value of ventilation-perfusion lung scanning in patients with suspected pulmonary embolism. Chest 1985; 88: 816-28.
- 17 The PIOPED investigators. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA 1990; 263: 2753-9.
- 18 van Beek EJR, Reekers JA, Batchelor DA, Brandjes DPM, Büller HR. Feasibility, safety and clinical utility of angiography in patients with suspected pulmonary embolism. Eur Radiol 1996; 06: 415-9.
- 19 Lensing AWA, Hirsh J, Büller HR. Diagnosis of venous thrombosis. In: Coleman RW, Hirsh J, Marder VJ, Salzman EW. Hemostasis and thrombosis. Basic principles and clinical practice. Philadelphia: JB Lippincott; 1994: 1297-321.
- 20 Wells PS, Lensing AWA, Davidson BL, Prins MH, Hirsh J. Accuracy of ultrasound for the diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. Ann Intern Med 1995; 122: 47-53.