Dependence on Prothrombin for Inhibition of Activated Protein C Activity by Lupus Antibodies

Susan L. Field; Colin N. Chesterman; Philip J. Hogg

doi:10.1055/s-0037-1614192

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2000; 84(06): 1132-1133
DOI: 10.1055/s-0037-1614192

Letters to the Editor

Schattauer GmbH

Dependence on Prothrombin for Inhibition of Activated Protein C Activity by Lupus Antibodies

Susan L. Field

¹From the Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales and Department of Haematology, South Eastern Laboratory Services, Sydney NSW, Australia

,

Colin N. Chesterman

¹From the Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales and Department of Haematology, South Eastern Laboratory Services, Sydney NSW, Australia

,

Philip J. Hogg

¹From the Centre for Thrombosis and Vascular Research, School of Pathology, University of New South Wales and Department of Haematology, South Eastern Laboratory Services, Sydney NSW, Australia

› Author Affiliations

Abstract

Full Text

References

References
1 Brighton TA, Chesterman CN. Antiphospholipid antibodies and thrombosis. Bailliére’s Clinical Haematology 1994; 07: 541-57.
2 Field SL, Hogg PJ, Daly EB, Dai Y-P, Murray B, Owens D, Chesterman CN. Lupus anticoagulants form immune complexes with prothrombin and phospholipid that can augment thrombin production in flow. Blood 1999; 94: 3421-31.
3 van de Waart P, Hemker HC, Lindhout T. Interaction of prothrombin with factor Va-phospholipid complexes. Biochemistry 1984; 23: 2838-42.
4 Nicolaes GAF, Tans G, Thomassen MCLGD, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J. Peptide bond cleavage and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 21158-66.
5 Camire RM, Kalafatis M, Cushman M, Tracy RP, Mann KG, Tracy PB. The mechanism of inactivation of human platelet factor Va from normal and activated protein C-resistant individuals. J Biol Chem 1995; 270: 20794-800.
6 Malia RG, Kitchen S, Greaves M, Preston FE. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br J Haem 1990; 76: 101-7.
7 Borrell M, Sala N, de Castellarnau C, Lopez S, Gari M, Fontcuberta J. Immunoglobulin fractions isolated from patients with antiphospholipid antibodies prevent inactivation of factor Va by activated protein C on human endothelial cells. Thromb Haemost 1992; 68: 268-72.
8 Oosting JD, Derksen RHWM, Bobbink IWG, Hackeng TM, Bouma BN, de Groot PG. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: An explanation for their pathogenic mechanism?. Blood 1993; 81: 2618-25.
9 Marciniak E, Romond E. Impaired catalytic function of activated protein C: A new in vitro manifestation of lupus anticoagulant. Blood 1989; 74: 2426-32.
10 Amer L, Kisiel W, Serales RP, Williams Jr RC. Impairment of the protein C anticoagulant pathway in a patient with systemic lupus erythematosus, anticardiolipin antibodies and thrombosis. Thromb Res 1990; 57: 247-58.
11 Lo SCL, Salem HH, Howard MA, Oldmeadow MJ, Firkin BG. Studies of natural anticoagulant proteins and anticardiolipin antibodies in patients with the lupus anticoagulant. Brit J Haematol 1990; 76: 380-6.