A nucleic acid exchange in Intron F (Intron F-14T>G) in the human plasminogen gene is only a common polymorphism and not a true mutation

• References

• 1 Sartori MT, Saggiorato G, Pellati D. et al.. Contraceptive pills induce an improvement in congenital hypoplasminogenemia in two unrelated patients with ligneous conjunctivitis. Thromb Haemost 2003; 90: 86-91.
• 2 Schuster V, Seregard S. Ligneous conjunctivitis. Surv Ophthalmol 2003; 48: 369-88.
• 3 Tefs K, Tail RC, Walker ID. et al.. A K19E missense mutation in the plasminogen gene is a common cause of familial hypoplasminogenemia. Blood Coagul Fibrinolysis 2003; 14: 411-6.
• 4 Schuster V, Seidenspinner S, Zeitler P. et al.. Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis. Blood 1999; 93: 3457-66.
• 5 Schuster V, Zeitler P, Seregard S. et al.. Homozygous and compound-heterozygous type I plasminogen deficiency is a common cause of ligneous conjunctivitis. Thromb Haemost 2001; 85: 1004-10.