Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position -675 in the promoter region

Thromb Haemost 2004; 92(05): 1164-1165
DOI: 10.1055/s-0037-1614298

Letters to the Editor

Schattauer GmbH

Anna Rita Bonfigli

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Cristina Sirolla

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Stefano Cenerelli

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Maurizio Marra

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Massimo Boemi

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Claudio Franceschi

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

,

Ivano Testa

²Institute of Internal Medicine, University of L’Aquila, L’Aquila, Italy

,

Daniela Mari

³IRCCS Maggiore Hospital, Dept. of Internal Medicine, Milan, Italy

,

Elisabetta Sacchi

⁴L. Sacco Hospital, Dept. of Immunology and Transfusion, Milan, Italy

,

Roberto Testa

¹INRCA, Italian National Research Center on Aging, Ancona, Italy

References
1 Nordt TK, Lohrmann J, Bode C. Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis. Thromb Res 2001; 103: S1-S5.
2 Panahloo A, Mohamed-Ali V, Lane A. et al. Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator 1 gene. Diabetes 1995; 44: 37-42.
3 Mertens I, Van Gaal LF. Obesity, haemostasis and the fibrinolytic system. Obesity reviews 2002; 03: 85-101.
4 Mannucci PM, Mari D, Merati G. et al. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol 1997; 17: 755-9.
5 Declerck PJ, Moreau H, Jespersen J. et al. Multicenter evaluation of commercially available methods for the immunological determination of plasminogen activator inhibitor-1 (PAI-1). Thromb Haemost 1993; 70: 858-63.
6 Olivieri F, Bonafe M, Cavallone L. et al. The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. Exp Gerontol 2002; 37: 309-14.
7 Bonafè M, Salvioli S, Barbi C. et al. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ 2004; 11: 962-73.