Thromb Haemost 1999; 82(04): 1376-1377
DOI: 10.1055/s-0037-1614404
Letters to the Editor
Schattauer GmbH

A Possible Solution to the Paradox of the “Lupus Anticoagulant”: Antiphospholipid Antibodies Accelerate Thrombin Generation by Inhibiting Annexin-V

Jacob H. Rand
1   From the Department of Medicine, Divisions of Hematology and Thrombosis, New York, NY, USA
,
Xiao-Xuan Wu
1   From the Department of Medicine, Divisions of Hematology and Thrombosis, New York, NY, USA
,
Peter Giesen
2   Mount Sinai School of Medicine, New York, NY, USA
› Institutsangaben
These studies were supported in part by a grant from the New York Community Trust and a Newman Research Followship.
Weitere Informationen

Publikationsverlauf

Received 05. April 1999

Accepted after resubmission 18. Juni 1999

Publikationsdatum:
08. Dezember 2017 (online)

 

 
  • References

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  • 2 Rand JH. The antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms. Am J Med Sci 1998; 316: 142-51.
  • 3 Rand JH, Wu XX, Andree HAM, Lockwood CJ, Guller S, Scher J, Harpel PC. Pregnancy loss in the antiphospholipid-antibody syndrome – a possible thrombogenic mechanism. N Engl J Med 1997; 337: 154-60.
  • 4 Rand JH, Wu XX, Andree HAM, Alexander Ross JB, Rosinova E, Gascon-Lema MG, Calandri C, Harpel PC. Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a »lupus procoagulant« phenomenon. Blood 1998; 92: 1652-60.
  • 5 Andree HAM, Stuart MC, Hermens WT, Reutelingsperger CP, Hemker HC, Frederik PM, Willems GM. Clustering of lipid-bound annexin V may explain its anticoagulant effect. J Biol Chem 1992; 267: 17907-12.