Performance of a New Fibrin Monomer Assay to Exclude Deep Vein Thrombosis in Symptomatic Outpatients

Christoph Caliezi; Nadja Fünfsinn; Thomas Mauron; Iris Baumgartner; Irmela Sulzer; Martin Ulrich; Christoph Cottier; Franziska Demarmels Biasiutti; Bernhard Lämmle; Walter A. Wuillemin

doi:10.1055/s-0037-1614417

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1999; 81(01): 50-53
DOI: 10.1055/s-0037-1614417

Review Article

Schattauer GmbH

Performance of a New Fibrin Monomer Assay to Exclude Deep Vein Thrombosis in Symptomatic Outpatients

Christoph Caliezi

,

Nadja Fünfsinn

,

Thomas Mauron

,

Iris Baumgartner

¹ From the Central Hematology Laboratory and Division of Angiology, Department of Internal Medicine, Switzerland

,

Irmela Sulzer

,

Martin Ulrich

² University Hospital, Inselspital Bern, and Division of Angiology, Department of Internal Medicine, Switzerland

,

Christoph Cottier

³ Regionalspital Biel and Department of Internal Medicine, Regionalspital Burgdorf, Switzerland

,

Franziska Demarmels Biasiutti

,

Bernhard Lämmle

,

Walter A. Wuillemin

› Institutsangaben

Abstract

Summary

In this study we prospectively assessed the reliability of a new fibrin monomer assay in 106 outpatients with clinically suspected deep venous thrombosis of the lower limb. According to the results of the objective tests and using different cut-off points we calculated the sensitivity, specificity and negative predictive value of the fibrin monomer assay. The prevalence of deep vein thrombosis was 44.3% (31.1% proximal, 13.2% distal). Using a cut-off level of plasma fibrin monomer of 3.5 μg/ml, a sensitivity, specificity and negative predictive value of 100% (95% CI: 94-100%), 35.6% (95% CI: 23-48%) and 100% (95% CI: 86-100%), respectively, were obtained. The exclusion rate was 19.8% (95% CI: 12-27%) of all referred patients. These accuracy indices compared favourably with the respective results of a routine D-dimer ELISA used for comparison. Conclusion: This new fibrin monomer assay appears to be a reliable method for the exclusion of deep vein thrombosis in symptomatic outpatients.

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Referenzen

References
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