The 20210 G to A Prothrombin Polymorphism and Late Complications in Type 1 Diabetes Mellitus

• References

• 1 Knöbl P, Schernthaner G, Schnack C, Pietschmann P, Griesmacher A, Müller M. Thrombogenic factors are related to urinary albumin excretion rate in type 1 and type 2 diabetic patients. Diabetologia 1993; 36: 1045-50.
• 2 Tschoepe D. The activated megakaryocyte-platelet-system in vascular disease: Focus on diabetes. Semin Thromb Hemost 1995; 23: 152-60.
• 3 Ruiz J. Diabetes mellitus and the late complications: influence of the genetic factors. Diabetes & Metabolism 1997; 23: 57-63.
• 4 Arruda VR Annichino-Bizacchi, Goncalves MS, Costa FF. Prevalence of the prothrombin gene variant (nt20210 A) in venous thrombosis and arterial disease. Thromb Haemost 1997; 78: 1430-3.
• 5 Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL. A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 1997; 90: 1747-50.
• 6 Ferraresi P, Marchetti G, Legnani C, Cavallari E, Castoldi E, Mascoli F, Ardissino D, Palareti G, Bernardi F. The heterozygous 20210 G/A pro-thrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease. Arteriosclerosis, Thrombosis and Vascular Biology 1997; 17: 2418-22.
• 7 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.