APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

U. Kjellberg; N.-E. Andersson; S. Rosén; L. Tengborn; M. Hellgren

doi:10.1055/s-0037-1614518

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(04): 527-531
DOI: 10.1055/s-0037-1614518

Rapid Communication

Schattauer GmbH

APC Resistance and other Haemostatic Variables during Pregnancy and Puerperium

U. Kjellberg

¹From the Dept. Obstet. Gyn., Sahlgrenska University Hospital, Gothenburg, Sweden

,

N.-E. Andersson

²Chromogenix AB, Mölndal, Sweden

,

S. Rosén

²Chromogenix AB, Mölndal, Sweden

,

L. Tengborn

³Coagulation Centre, Dept. Intern. Med., Sahlgrenska University Hospital, Gothenburg, Sweden

,

M. Hellgren

¹From the Dept. Obstet. Gyn., Sahlgrenska University Hospital, Gothenburg, Sweden

› Author Affiliations

Abstract

Summary

Forty-eight healthy pregnant women were studied prospectively and longitudinally. Blood sampling was performed at 10-15, 23-25, 32-34 and 38-40 weeks of gestation, within one week and at eight weeks postpartum. Classic and modified activated protein C ratio decreased as pregnancy progressed. In the third trimester 92% of the ratios measured with the classic test were above the lower reference level whereas all modified test ratios were normal. Slight activation of blood coagulation was shown with increased levels of prothrombin fragment 1+2, soluble fibrin and D-dimer. Fibrinogen, factor VIII and plasminogen activator inhibitor type 1 and type 2 increased. Protein S and tissue plasminogen activator activity decreased. Protein C remained unchanged. No correlation was found between the decrease in classic APC ratio and changes in factor VIII, fibrinogen, protein S, prothrombin fragment 1+2 or soluble fibrin, nor between the increase in soluble fibrin and changes in prothrombin fragment 1+2, fibrinogen and D-dimer.

Full Text

References

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