Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids

Ingebjørg Seljeflot; Odd Johansen; Harald Arnesen; Jan-Bertil Eggesbø; Åse-Britt Westvik; Peter Kierulf

doi:10.1055/s-0037-1614525

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(04): 566-570
DOI: 10.1055/s-0037-1614525

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Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids

Ingebjørg Seljeflot

,

Odd Johansen

¹From the Research Forum, Dept of Medicine, Ullevål University Hospital, Oslo, Norway

,

Harald Arnesen

¹From the Research Forum, Dept of Medicine, Ullevål University Hospital, Oslo, Norway

,

Jan-Bertil Eggesbø

²Research and Development Group, Dept of Clinical Chemistry, Ullevål University Hospital, Oslo, Norway

,

Åse-Britt Westvik

²Research and Development Group, Dept of Clinical Chemistry, Ullevål University Hospital, Oslo, Norway

,

Peter Kierulf

²Research and Development Group, Dept of Clinical Chemistry, Ullevål University Hospital, Oslo, Norway

› Author Affiliations

Abstract

Summary

Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 patients had been on placebo (group II). All patients were then given 5.1g n-3 FA daily for another 4 weeks.

At baseline significantly lower levels of LPS-induced prothrombin fragment₁₊₂ were found in group I (p = 0.010), this difference being eliminated after 4 weeks. Il-6 and TNF_αwere significantly higher at baseline in group I and the differences in changes from baseline between the groups were statistically highly significant with increasing values in group II (Il-6 p = 0.001, TNF_αp = 0.002).

The present results indicate a reduction in pro-thrombotic potential in patients receiving highly concentrated n-3 FA, whereas some pro-inflammatory responses might be adverse.

Full Text

References

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