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Thromb Haemost 1999; 81(04): 657
DOI: 10.1055/s-0037-1614541
Letters to the Editor
Schattauer GmbH

The Inactivation of Single-chain Urokinase-type Plasminogen Activator by Thrombin May Provide an Additional Explanation for the Antifibrinolytic Effect of Factor XI

E. A. M. Braat
1   From TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
,
D. C. Rijken
1   From TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
› Institutsangaben
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Publikationsverlauf

Received 30. November 1998

Accepted after revision 08. Januar 1999

Publikationsdatum:
09. Dezember 2017 (online)

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  • References

  • 1 Bouma BN, von dem Borne PAK, Meijers JCM. Factor XI and protection of the fibrin clot against lysis – a role for the intrinsic pathway of coagulation in fibrinolysis. Thromb Haemost 1998; 80: 24-7.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 2 Gurewich V, Pannell R. Inactivation of single-chain urokinase-type plasminogen activator (pro-urokinase) by thrombin and thrombin-like enzymes: relevance of the findings to the interpretation of fibrin-binding experiments. Blood 1987; 69: 769-72.
    PubMedGoogle Scholar
  • 3 Lijnen HR, van Hoef B, Collen D. Activation with plasmin of two-chain urokinase-type plasminogen activator derived from single-chain urokinase-type plasminogen activator by treatment of thrombin. Eur J Biochem 1987; 169: 359-64.
    CrossrefPubMedGoogle Scholar
  • 4 Braat EAM, Los P, Rijken DC. The inactivation of single-chain urokinase-type plasminogen activator by thrombin in a plasma milieu: effect of thrombomodulin. Blood Coag Fibrinol 1998; 9: 419-27.
    CrossrefPubMedGoogle Scholar
  • 5 Bajzar L, Manuel R, Nesheim ME. Purification and characterization of TAFI, a thrombin-activatable fibrinolysis inhibitor. J Biol Chem 1995; 270: 14477-84.
    CrossrefPubMedGoogle Scholar
  • 6 von dem Borne PAK, Meijers JCM, Bouma BN. Feedback activation of factor XI by thrombin in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis. Blood 1995; 86: 3035-42.
    PubMedGoogle Scholar
  • 7 von dem Borne PAK, Bajzar L, Meijers JCM, Nesheim ME, Bouma BN. Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis. J Clin Invest 1997; 99: 2323-7.
    CrossrefPubMedGoogle Scholar
  • 8 Bajzar L, Morser J, Nesheim M. TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombinthrombomodulin complex. J Biol Chem 1996; 271: 16603-8.
    CrossrefPubMedGoogle Scholar
  • 9 Sakharov DV, Plow EF, Rijken DC. On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B. J Biol Chem 1997; 272: 14477-82.
    CrossrefPubMedGoogle Scholar
  • 10 De Munk GAW, Groeneveld E, Rijken DC. Acceleration of the thrombin inactivation of single-chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin. J Clin Invest 1991; 88: 1680-4.
    CrossrefPubMedGoogle Scholar