High Prevalence of Factor V Leiden Mutation and 20210A Prothrombin Variant in Hungary

I. Balogh; R. Póka; G. Pfliegler; M. Dékány; Z. Boda; L. Muszbek

doi:10.1055/s-0037-1614544

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(04): 660-661
DOI: 10.1055/s-0037-1614544

Letters to the Editor

Schattauer GmbH

High Prevalence of Factor V Leiden Mutation and 20210A Prothrombin Variant in Hungary

I. Balogh

¹From the Department of Clinical Biochemistry and Molecular Pathology, Debrecen, Hungary

,

R. Póka

²Department of Obstetrics and Gynecology, University Medical School, Debrecen, Hungary

,

G. Pfliegler

³2nd Departement of Internal Medicine, University Medical School, Debrecen, Hungary

,

M. Dékány

⁴Markhot F. County Hospital, Eger, Hungary

,

Z. Boda

³2nd Departement of Internal Medicine, University Medical School, Debrecen, Hungary

,

L. Muszbek

¹From the Department of Clinical Biochemistry and Molecular Pathology, Debrecen, Hungary

› Author Affiliations

Abstract

Full Text

References

References
1 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
2 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
3 Rees DC, Cox MJ, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
4 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
5 Rees DC. The population genetics of factor V Leiden (Arg506Gln). Brit J Haematol 1996; 95: 579-86.
6 Koeleman PBC, Reitsma PH, Allaart CF, Bertina RM. Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families. Blood 1994; 84: 1031-5.
7 Tordai A, Klein I, Rajczy K, Pénzes M, Sarkadi B, Váradi A. Prevalence of factor V Leiden (Arg506Gln) in Hungary. Brit J Haematol 1997; 99: 466-7.
8 Akar N, Akar E, Dalgin G, Sözüöz A, Ömürlü K, Cin S. Frequency of factor V (1691 G-A) mutation in Turkish population. Thromb Haemost 1997; 78: 1527-8.
9 Zoller B, Norlund L, Leksell H, Nilsson JE, von Schenk H, Rosen U, Jepsson JO, Dahlback B. High prevalence of the FVR506Q mutation causing APC resistance in a region of southern Sweden with a high incidence of venous thrombosis. Thromb Res 1996; 83: 475-7.
10 Gurgey A, Rustemov R, Parlak H, Balta G. Prevalence of factor V Leiden and methylenetetrahydrofolate reductase C677T mutations in Azerbaijan. Thromb Haemost 1998; 80: 520-1.