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Thromb Haemost 1999; 81(06): 857-860
DOI: 10.1055/s-0037-1614587
Letters to the Editor
Schattauer GmbH

Factor V Q506 (Resistance to Activated Protein C) and Prognosis after Acute Coronary Syndrome

Johan Holm
1   From the Department of Cardiology and Coagulation Disorders, University Hospital, Malmö, Sweden
,
Andreas Hillarp
2   Department of Clinical Chemistry and Coagulation Disorders, University Hospital, Malmö, Sweden
,
Bengt Zöller
2   Department of Clinical Chemistry and Coagulation Disorders, University Hospital, Malmö, Sweden
,
Leif Erhardt
1   From the Department of Cardiology and Coagulation Disorders, University Hospital, Malmö, Sweden
,
Erik Berntorp
2   Department of Clinical Chemistry and Coagulation Disorders, University Hospital, Malmö, Sweden
,
Björn Dahlbäck
2   Department of Clinical Chemistry and Coagulation Disorders, University Hospital, Malmö, Sweden
› Author Affiliations
Further Information

Publication History

Received 22 September 1998

Accepted after resubmission 11 March 1999

Publication Date:
09 December 2017 (online)

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Summary

Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.

 

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