Age- and Sex-related Differences of Plasma Activated Factor VII Levels in Children

Toshiyuki Sakata; Taku Yamamura; Kazuomi Kario; Yoshiaki Katayama; Tatsuo Matsuyama; Hisao Kato; Akira Yamamoto; Toshiyuki Miyata

doi:10.1055/s-0037-1614597

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 81(06): 910-912
DOI: 10.1055/s-0037-1614597

Letters to the Editor

Schattauer GmbH

Age- and Sex-related Differences of Plasma Activated Factor VII Levels in Children

Toshiyuki Sakata

¹From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan

,

Taku Yamamura

²Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan

,

Kazuomi Kario

³Department of Cardiology, Jichi Medical School, Tochigi, Japan

,

Yoshiaki Katayama

¹From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan

,

Tatsuo Matsuyama

¹From Laboratory of Clinical Chemistry, and Suita, Osaka, Tochigi, Japan

,

Hisao Kato

²Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan

,

Akira Yamamoto

²Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan

,

Toshiyuki Miyata

²Research Institute, National Cardiovascular Center, Suita, Osaka, and the Tochigi, Japan

› Author Affiliations

Abstract

Summary

Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) exist in plasma and play an important role in the initiation of tissue factor-induced coagulation. It has been reported that the concentrations of hemostatic components in children and adults are different. Here, we investigated the age- and sex-related differences of FVIIa and FVII antigen (FVIIag) levels in children at age of 10 (n = 123; males: n = 62; females: n = 61), and 13 (n = 105; males: n = 47; females: n = 58), and compared these levels with those of young adults (mean ± SD of age: 29.6 ± 6.0 years). In males, there was not a significant difference between the FVIIa levels of 10-year-old children and 13-year-old children, but the FVIIa levels in adult controls were significantly higher than those in children. In females, the FVIIa levels in 13-year-old children were significantly higher than that in 10-year-old children, but there was not a significant difference between 13-year-old children and adults. Thus, our study showed that plasma FVIIa levels were lower in children than in adults, and the increase of FVIIa level was earlier in females than in males.

Full Text

References

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