Non-specific Inhibition of ADP-induced Platelet Antiaggregation by Clopidogrel In Vitro

• References

• 1 Weber AA, Reimann S, Schror K. Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro. Br J Pharmacol 1999; 126 (02) 415-20.
• 2 Herbert JM, Frehel D, Vallée E, Kieffer G, Gouy D, Berger Y, Necciari J, Defreyn G, Maffrand JP. Clopidogrel, a novel antiplatelet and antithrombotic agent. Cardiovasc Drug Rev 1993; 11: 180-98.
• 3 Savi P, Herbert JM, Pflieger AM, Dol F, Delebassée D, Combalbert J, Defreyn G, Maffrand JP. Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel. Biochem Pharmacol 1992; 44: 527-32.
• 4 Savi P, Combalbert J, Gaich C, Rouchon MC, Maffrand JP, Berger Y, Herbert JM. The antiaggregating activity of clopidogrel is due to a metabolic activation by hepatic cytochrome P450-1A. Thromb Haemost 1994; 72: 313-7.
• 5 Defreyn G, Gachet C, Savi P, Driot F, Cazenave JP, Maffrand JP. Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits. Thromb Haemost 1991; 65: 186-90.
• 6 Holme S, Sixma JJ, Wester J, Holmsen H. ADP-induced refractory state of platelets in vitro. II-Functional and ultra studies on gel filtered platelets. Scand J Haematol 1977; 18: 267-78.
• 7 Mills DCB, Puri R, Hu C-J, Minniti C, Grana G, Freedman MD, Colman RF, Colman RW. Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase. Arteriosclerosis and thrombosis 1992; 12: 430-6.
• 8 Savi P, Laplace MC, Maffrand JP, Herbert JM. Binding of ³H-2-methylthio ADP to rat platelets: effect of clopidogrel and ticlopidine. J Pharm Exp Ther 1994; 269: 772-7.
• 9 Gambino MC, Passaghe S, Chen ZM, Bucchi F, Gori G, Latini R, De Gaetano G, Cerletti C. Selectivity of oral aspirin as an inhibitor of platelet vs. vascular cyclooxygenase activity is reduced by portacaval shunt in rats. J Pharmacol Exp Ther 1988; 245: 287-90.
• 10 Savi P, Pereillo JM, Fedeli O, Maftouh M, Uzabiaga MF, Berger Y, Necciari J, Rouchon MC, Combalbert J, Picard C, Maffrand JP, Pascal M, Herbert JM. Structure and Activity of the Active Metabolite of Clopidogrel. Submitted