Thromb Haemost 1998; 79(03): 686-687
DOI: 10.1055/s-0037-1614968
Letters to the Editor
Schattauer GmbH

Prevalence of the 677C to T Mutation in the Methylenetetrahydrofolate Reductase Gene in Italian Patients with Venous Thrombotic Disease

Valerio De Stefano
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Patrizia Chiusolo
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Katia Paciaroni
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Fabio G. Serra
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Maria Teresa Voso
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Ida Casorelli
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Elena Rossi
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
,
Giuseppe Leone
1   Department of Hematology and the Department of Pathology, Catholic University, Rome, Italy
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 15. Dezember 1998

Accepted after revision 29. Oktober 1998

Publikationsdatum:
07. Dezember 2017 (online)

 

 
  • References

  • 1 Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease.. N Engl J Med 1991; 324: 1149-55.
  • 2 Falcon CR, Cattaneo M, Panzeri D, Martinelli I, Mannucci PM. High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.. Arterioscler Thromb 1994; 14: 1080-3.
  • 3 Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.. Circulation 1996; 93: 7-9.
  • 4 Kluijtmans LAJ, van den Heuvel LPWJ, Boers GHJ, Frosst P, Stevens EMB, van Oost BA, den Heijer M, Trijbels FJM, Rozen R, Blom HJ. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.. Am J Hum Genet 1996; 58: 35-41.
  • 5 Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHRF) as a risk factor for coronary artery disease.. Circulation 1998; 95: 2032-6.
  • 6 Arruda VR, von Zuben PM, Chiaparini LC, Annichino-Bizzacchi JM, Costa FF. The mutation Ala677→Val in the methylene tetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis.. Thromb Haemost 1998; 77: 818-21.
  • 7 Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuvel LP, Rozen R. A candidate genetic risk factor for vascular disease: a common mutation in methylene tetrahydrofolate reductase.. Nature Genet 1995; 10: 111-3.
  • 8 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C.. Nature 1994; 369: 64-7.
  • 9 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.. Blood 1996; 88: 3698-703.
  • 10 de Franchis R, Sebastio G, Mandato C, Andria G, Mastroiacovo P. Spina bifida, 677C→T mutation, and role of folate.. Lancet 1995; 346: 1703.
  • 11 Tosetto A, Missiaglia E, Frezzato M, Rodeghiero F. The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism.. Br J Haematol 1998; 97: 804-6.
  • 12 Sacchi E, Tagliabue L, Duca F, Mannucci PM. High frequency of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in Northern Italy.. Thromb Haemost 1998; 78: 963-4.