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Thromb Haemost 1998; 79(06): 1119-1125
DOI: 10.1055/s-0037-1615027
Rapid Communication
Schattauer GmbH

Increased Potency and Decreased Elimination of Lamifiban, a GPIIb-IIIa Antagonist, in Patients with Severe Renal Dysfunction

Gustav Lehne
1   From the Departments of Clinical Pharmacology, Drug Research Unit, Oslo, Norway
,
Knut P. Nordal
2   Internal Medicine, The National Hospital, Rikshospitalet, Oslo, Norway
,
Karsten Midtvedt
2   Internal Medicine, The National Hospital, Rikshospitalet, Oslo, Norway
,
Timothy Goggin
3   Department of Clinical Pharmacology, F. Hoffmann-La Roche AG, Basel, Switzerland
,
Frank Brosstad
2   Internal Medicine, The National Hospital, Rikshospitalet, Oslo, Norway
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 28. Juli 1997

Accepted after resubmission 11. Februar 1998

Publikationsdatum:
07. Dezember 2017 (online)

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Summary

Activation of the platelet membrane receptor glycoprotein (GP) IIb-IIIa is essential for thrombus formation. The novel nonpeptide GPIIb-IIIa antagonist, lamifiban, represents a promising approach for antiplatelet therapy in patients with cardiovascular disease. Since renal impairment frequently occurs in these patients, we designed a phase I study to assess the tolerability, pharmacodynamics and pharmacokinetics of lamifiban in patients with renal impairment. Four healthy volunteers (Group 1) with creatinine clearance (CLCR) >75 ml/min, eight patients (Group 2) with mild to moderately impaired renal function (CLCR 30-74 ml/min) and eight patients (Group 3) with severe renal impairment (CLCR 10-29 ml/min) were studied. They received stepwise increased doses of lamifiban intravenously (IV). There was a linear relationship between the systemic clearance of the drug and renal function (R2 = 0.86). The mean plasma concentration required for half-maximal inhibition of thrombin-receptor agonist peptide (TRAP) induced platelet aggregation (EC50) ex vivo was 21, 28 and 11 ng/ml in Groups 1, 2 and 3. The patients in Group 3 were sensitized to the anti-platelet effect allowing an 18-fold dosage reduction without compromising the pharmacodynamics. In conclusion, the decreased clearance of lamifiban may act in concert with increased potency of the drug in patients with severe renal impairment, and the drug dosage should be reduced accordingly.

 

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