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Thromb Haemost 1998; 79(04): 731-735
DOI: 10.1055/s-0037-1615054
Rapid Communication
Schattauer GmbH

Polymorphism of Platelet Membrane Glycoprotein IIIa: Human Platelet Antigen 1b (HPA-1b/PlA2) Is an Inherited Risk Factor for Premature Myocardial Infarction in Coronary Artery Disease

Rainer B. Zotz
1   From the Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Bernhard R. Winkelmann
2   From the Department of Cardiology, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany
,
Markus Nauck
3   From the Division of Clinical Chemistry, Albert Ludwigs University, Freiburg, Germany
,
Günther Giers
1   From the Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Beate Maruhn-Debowski
1   From the Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Winfried März
3   From the Division of Clinical Chemistry, Albert Ludwigs University, Freiburg, Germany
,
Rüdiger E. Scharf
1   From the Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Düsseldorf, Germany
› InstitutsangabenSupported in part by a grant (Sch 358/1-3) from the Deutsche Forschungsgemeinschaft, Bonn, Germany
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Publikationsverlauf

Received 28. August 1997

Accepted after revision 02. Dezember 1997

Publikationsdatum:
07. Dezember 2017 (online)

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Summary

Conflicting results of an association between the human platelet antigen 1b (HPA-1b or PlA2) allele and the risk of myocardial infarction and coronary artery disease have been reported. To assess the reason for this discrepancy, we determined the HPA-1 genotype in 298 men who had undergone coronary angiography, including 124 individuals with myocardial infarction, 83 individuals with coronary artery disease but no history of myocardial infarction, and 91 control patients. Among patients with acute or recent onset myocardial infarction (<1 year), the prevalence of HPA-1b was higher than among patients with coronary artery disease but without myocardial infarction (33 percent vs. 14 percent, p = 0.016). In patients under 60 years of age this difference was even more pronounced (45 percent vs. 15 percent, p = 0.003). Unlike conventional risk factors HPA-1b does not represent a risk factor for coronary artery disease itself but appears to be associated with increased platelet thrombogenicity.

 

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