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Thromb Haemost 1998; 79(04): 837-842
DOI: 10.1055/s-0037-1615074
Rapid Communication
Schattauer GmbH

Relations of Platelet Ca2+ Handling and Membrane Microviscosity to Vascular Tone and Restenosis after Angioplasty in Human Coronary Artery

Claude Le Feuvre
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Kim-Hanh Le Quan Sang
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
,
Annie Brunet
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
,
Didier Catuli
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Jean-Philippe Metzger
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
André Vacheron
1   From the Clinique Cardiologique, Hôpital Necker-Enfants Malades, Paris, France
,
Marie-Aude Devynck
2   From the Pharmacologie, CNRS URA 1482, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
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Publikationsverlauf

Received 07. März 1997

Accepted after resubmission 24. November 1997

Publikationsdatum:
07. Dezember 2017 (online)

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Summary

This study was designed to assess whether platelet Ca2+ handling or membrane microviscosity could be considered as indexes of vascular tone, or could help to predict an increased risk of restenosis after coronary angioplasty. Vascular tone was quantified in 21 patients with stable angina by the vasodilator response to sin-1 intracoronary injection in the reference coronary segment and by the importance of the acute recoil after angioplasty in the narrowed segment. The degree of restenosis was quantified by coronary angiography 6 months later.

Individual values of relative sin-1-induced changes in the reference coronary diameter were positively correlated with cytosolic Ca2+ concentration in unstimulated platelets, irrespective of the extracellular Ca2+ concentration (p <0.01). This relationship was also observed with the thrombin-evoked Ca2+ changes, measured in the absence of a Ca2+ influx (p = 0.01). No relationship was found between sin-1-induced coronary changes and membrane microviscosity evaluated by TMADPH and DPH anisotropies or platelet volume, or between degree of acute recoil and platelet characteristics.

In conclusion, platelet Ca2+ reflects the vasodilating efficacy in response to sin-1, but cannot help to predict restenosis after coronary angioplasty.

 

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