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Thromb Haemost 1998; 79(05): 1056-1057
DOI: 10.1055/s-0037-1615122
DOI: 10.1055/s-0037-1615122
Letters to the Editor
Methylene Tetrahydrofolate Reductase (MTHFR) 677T→C Mutation and Unexplained Early Pregnancy Loss
Further Information
Publication History
Received
03 December 1997
Accepted after revision
20 January 1998
Publication Date:
07 December 2017 (online)
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References
- 1 Nelen WLDM, Steegers EAP, Eskes TKA, Blom HJ. Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 1997; 350: 861.
- 2 Steegers-Theunissen RPM, Boers GHJ, Blom HJ, Trijbels FJM, Eskes TKAB. Hyperhomocysteinemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992; 339: 1122-3.
- 3 Grandone E, Margaglione M, Colaizzo D. et al. Factor V Leiden is associated with repeated and recurrent fetal losses. Thromb Haemost 1997; 77: 822-4.
- 4 De Franchis R, Mancini FP, D’Angelo A. et al. Elevated total plasma homocysteine and 677C→T mutation of the 5,10-Methylenetetrahydrofolate reductase gene in thrombotic vascular disease. Am J Hum Genet 1996; 59: 262-4.
- 5 Guttormsen AB, Ueland PM, Nesthus I. et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/liter). J Clin Invest 1996; 98: 2174-83.