Coronary Thrombosis and the Platelet Glycoprotein IIIA Gene PLA2 Polymorphism

Emanuele Durante-Mangoni; Graham J. Davies; Nabeel Ahmed; Giuseppe Ruggiero; Edward G. Tuddenham

doi:10.1055/s-0037-1615175

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1998; 80(02): 218-219
DOI: 10.1055/s-0037-1615175

Rapid Communication

Schattauer GmbH

Coronary Thrombosis and the Platelet Glycoprotein IIIA Gene PLA² Polymorphism

Autoren

Emanuele Durante-Mangoni

¹Institute of Medical Therapy, 2nd University of Naples Medical School, Naples, Italy
Graham J. Davies

²Imperial College School of Medicine
Nabeel Ahmed

²Imperial College School of Medicine
Giuseppe Ruggiero

¹Institute of Medical Therapy, 2nd University of Naples Medical School, Naples, Italy
Edward G. Tuddenham

³Medical Research Council at Hammersmith Hospital, London, UK

Abstract

Summary

Myocardial infarction results from a platelet-rich occlusive coronary thrombus. Platelet membrane glycoprotein IIb/IIIa plays an important role in platelet adhesion and aggregation. Two polymorphisms of the gene encoding the IIIa subunit, PLA¹ and PLA², have been identified. We investigated the frequency of these polymorphisms in 114 consecutive patients with a history of angina-like chest pain admitted for coronary arteriography. Forty-three of these patients had previously suffered a myocardial infarction. The PLA² polymorphism was found in 21% of the patients with previous myocardial infarction and in 27% of the patients with angina-like chest pain but no previous myocardial infarction (p = 0.634). There was also no significant association with the extent of coronary disease. There is no evidence, therefore, from this study of an association between the PLA polymorphisms and the occurrence of myocardial infarction.

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Referenzen

References
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