Induction of Endothelial Cell Adhesion Molecules by Serum and Immunoglobulins G from a Patient with Vasculitis and Monoclonal Gammapathy: Potential Relevance to Vasculitis

Evelyne Dupuy; Jean-Marc Herbert; Véronique Giraudeau; Isabelle Quere; Jean-Marc Zini; Gérard Tobelem

doi:10.1055/s-0037-1615232

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1998; 80(03): 477-480
DOI: 10.1055/s-0037-1615232

Rapid Communications

Schattauer GmbH

Induction of Endothelial Cell Adhesion Molecules by Serum and Immunoglobulins G from a Patient with Vasculitis and Monoclonal Gammapathy: Potential Relevance to Vasculitis

Evelyne Dupuy

¹From the Department of Hematology

,

Jean-Marc Herbert

³From the Sanofi Recherche, Toulouse, France

,

Véronique Giraudeau

²From the Laboratory of Biochemistry, Hôpital Lariboisière, Paris

,

Isabelle Quere

¹From the Department of Hematology

,

Jean-Marc Zini

¹From the Department of Hematology

,

Gérard Tobelem

¹From the Department of Hematology

› Institutsangaben

Abstract

Summary

Interactions between endothelial cell adhesion molecules and their β₂ integrin adhesive receptors on leukocytes are thought to play a role in the pathogenesis of inflammatory diseases and probably vasculitis. We describe a case in whom leukocytoclastic vasculitis was associated to a monoclonal immunoglobulin G₂ kappa (IgG₂K). During the vasculitic crisis, the patient’s serum and the isolated IgG from this serum induced the expression of E-selectin, VCAM-1 and ICAM-1 at the HUVEC surface, but not tissue factor activity, whereas normal, control serum and patient serum at remission were without any effect.

A close relationship between the vasculitis and the serum level of the monoclonal IgG was observed. We suggest that the monoclonal IgG might induce the vasculitis by increasing the expression of E-selectin, VCAM-1 and ICAM-1 which facilitate the interaction of leukocytes with vascular endothelium.

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Referenzen

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