Coagulation Factor XIII and Cardiovascular Disease in UK Asian Patients Undergoing Coronary Angiography

Darren Warner; Michael W. Mansfield; Peter J. Grant

doi:10.1055/s-0037-1615597

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 85(03): 408-411
DOI: 10.1055/s-0037-1615597

Review Article

Schattauer GmbH

Coagulation Factor XIII and Cardiovascular Disease in UK Asian Patients Undergoing Coronary Angiography

Darren Warner

¹Academic Unit of Molecular Vascular Medicine, Research School of Medicine, The University of Leeds, UK

,

Michael W. Mansfield

¹Academic Unit of Molecular Vascular Medicine, Research School of Medicine, The University of Leeds, UK

,

Peter J. Grant

¹Academic Unit of Molecular Vascular Medicine, Research School of Medicine, The University of Leeds, UK

› Institutsangaben

Abstract

Summary

Possession of the coagulation factor XIII Val34Leu (FXIIIVal34Leu) polymorphism is associated with protection against myocardial infarction (MI) in Caucasians, in the absence of features of insulin resistance. The role of this polymorphism in the UK Asian population, with its high prevalence of insulin resistance and ischaemic heart disease, is unknown. We investigated the frequency of genotypes at this polymorphism, and measures of circulating FXIII in a group of UK Asians attending for coronary angiography. Genotype at the FXIIIVal34Leu polymorphism was not associated with MI. FXIII B-subunit levels correlated with waist: hip ratio (r = 0.19, p 0.005), HbA1c (r = 0.18, p 0.05), fasting triglycerides (r = 0.21, p 0.005), total cholesterol (r = 0.29, p 0.0005) and PAI-1 antigen (r = 0.24, p 0.005). An association between FXIIIVal34Leu and FXIII cross-linking activity was confirmed in these subjects (one-way ANOVA p 0.0005). This evidence does not support the hypothesis that FXIIIVal34Leu is protective against MI in the UK Asian population. FXIII B-subunit levels are strongly linked to risk factors for cardiovascular disease, suggesting an underlying association with insulin resistance.

Keywords

Polymorphism - ethnicity - cardiovascular disease - factor XIII - risk factors

Volltext

Referenzen

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