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Thromb Haemost 2001; 85(04): 584-595
DOI: 10.1055/s-0037-1615638
Review Articles
Schattauer GmbH

Hemostatic Risk Factors and Arterial Thrombotic Disease

Alexander P. Reiner
1   Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
,
David S. Siscovick
1   Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
,
Frits R. Rosendaal
2   The Hemostasis and Thrombosis Research Center and Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands
› Author Affiliations
Further Information

Publication History

Publication Date:
08 December 2017 (online)

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Summary

The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental factors related to atherosclerosis and thrombosis. Acute thrombosis at the site of a ruptured, lipid-rich atherosclerotic plaque is the usual precipitating event in the transition from stable or subclinical atherosclerotic disease to acute myocardial infarction (MI), stroke, or peripheral arterial occlusion (1). Pathologic studies of coronary arteries in acute MI suggest that the acute thrombosis likely involves activation of both platelets and the coagulation system.

 

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