Hemostatic Risk Factors and Arterial Thrombotic Disease

Alexander P. Reiner; David S. Siscovick; Frits R. Rosendaal

doi:10.1055/s-0037-1615638

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(04): 584-595
DOI: 10.1055/s-0037-1615638

Review Articles

Schattauer GmbH

Hemostatic Risk Factors and Arterial Thrombotic Disease

Authors

Alexander P. Reiner

¹Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
David S. Siscovick

¹Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA
Frits R. Rosendaal

²The Hemostasis and Thrombosis Research Center and Department of Clinical Epidemiology, University Hospital Leiden, The Netherlands

Abstract

Summary

The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental factors related to atherosclerosis and thrombosis. Acute thrombosis at the site of a ruptured, lipid-rich atherosclerotic plaque is the usual precipitating event in the transition from stable or subclinical atherosclerotic disease to acute myocardial infarction (MI), stroke, or peripheral arterial occlusion (1). Pathologic studies of coronary arteries in acute MI suggest that the acute thrombosis likely involves activation of both platelets and the coagulation system.

Full Text

References

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