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Thromb Haemost 2001; 85(02): 356-361
DOI: 10.1055/s-0037-1615692
Review Article
Schattauer GmbH

Expression and Anticoagulant Function of the Endothelial Cell Protein C Receptor (EPCR) in Cancer Cell Lines

Naoko Tsuneyoshi
1   Department of Immunology, Saga Medical School, Saga, Japan
,
Kenji Fukudome
1   Department of Immunology, Saga Medical School, Saga, Japan
5   Department of Immunology
,
Shin-ichiro Horiguchi
3   Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
,
Xiaofen Ye
1   Department of Immunology, Saga Medical School, Saga, Japan
,
Miwako Matsuzaki
2   Department of Internal Medicine, Saga Medical School, Saga, Japan
,
Masakazu Toi
3   Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
,
Koji Suzuki
4   Department of Molecular Pathobiology, Mie University School of Medicine, Tsu-City, Mie, Japan
,
Masao Kimoto
1   Department of Immunology, Saga Medical School, Saga, Japan
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Publikationsverlauf

Received 07. Juni 2000

Accepted after revision 13. September 2000

Publikationsdatum:
08. Dezember 2017 (online)

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Summary

Induction of procoagulant factors in malignant cells is considered to be the major cause of coagulation disorders in cancer. Thrombomodulin (TM), a negative regulator of coagulation was also found to be expressed in cancer cells. We report here evidence for another anticoagulant, the endothelial cell protein C receptor (EPCR), in cancer cells. EPCR was detected in several cell lines derived from various types of cancer. Significant levels of protein C (PC) activation were detected only with cell lines expressed both EPCR and TM. Anti-EPCR monoclonal antibodies (mAbs) specifically inhibited the activation. Thus, EPCR function appears to be important for PC activation by cancer cells. In addition, we detected EPCR expression in tumor cells from breast cancer patients, with an extremely high frequency. EPCR function may contribute to progression or pathogenesis of some types of cancer, and may explain the complexity of coagulopathy in cancer patients.

Keywords

Protein C - endothelial cell - receptor - glioblastoma - leukemia
 

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