The E27 β2-adrenergic Receptor Polymorphism Reduces the Risk of Myocardial Infarction in Dyslipidemic Young Males

Gianluca Sala; Augusto Di Castelnuovo; Laura Cuomo; Marinella Gattone; Pantaleo Giannuzzi; Licia Iacoviello; Antonio De Blasi

doi:10.1055/s-0037-1615699

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 85(02): 231-233
DOI: 10.1055/s-0037-1615699

Review Article

Schattauer GmbH

The E27 β₂-adrenergic Receptor Polymorphism Reduces the Risk of Myocardial Infarction in Dyslipidemic Young Males

Gianluca Sala

¹Department of Molecular Pharmacology and Pathology, Consorzio Mario Negri Sud, Istituto di Ricerche Farmacologiche “Mario Negri”, Santa Maria Imbaro, Italy

,

Augusto Di Castelnuovo

²Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Istituto di Ricerche Farmacologiche “Mario Negri”, Santa Maria Imbaro, Italy

,

Laura Cuomo

³I.N.M. Neuromed Pozzilli, Italy

,

Marinella Gattone

⁴Cardiology Department, “Salvatore Maugeri” Foundation, IRCCS, Institute for Clinical Care and Research, Medical Center of Rehabilitation, Veruno, Italy

,

Pantaleo Giannuzzi

⁴Cardiology Department, “Salvatore Maugeri” Foundation, IRCCS, Institute for Clinical Care and Research, Medical Center of Rehabilitation, Veruno, Italy

,

Licia Iacoviello

³I.N.M. Neuromed Pozzilli, Italy

,

Antonio De Blasi

¹Department of Molecular Pharmacology and Pathology, Consorzio Mario Negri Sud, Istituto di Ricerche Farmacologiche “Mario Negri”, Santa Maria Imbaro, Italy

³I.N.M. Neuromed Pozzilli, Italy

› Author Affiliations

Abstract

Summary

In the present study we evaluated whether two polymorphisms of β₂-adrenergic receptors (β₂-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI).

Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P<0.001) compared with normolipidemia in the entire study population, the relative risk increased to 9.0 (P<0.001) in Q27 homozygotes with dyslipidemia, and decreased to 1.8 (P=0.36) in E27 homozygotes.

Our results show that the E27 allele of the β₂-adrenergic receptor has a significant protective effect on MI in dyslipidemic young male.

Keywords

β₂-adrenergic receptor polymorphisms - myocardial infarction - dyslipidemia

Full Text

References

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