Antibodies to Phosphatidylethanolamine as the only Antiphospholipid Antibodies Found in Patients with Unexplained Thromboses

Marielle Sanmarco; Marie-Christine Alessi; Jean Robert Harle; Christophe Sapin; Marie-Françoise Aillaud; Stéphanie Gentile; Irène Juhan-Vague; Pierre-Jean Weiller

doi:10.1055/s-0037-1615751

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2001; 85(05): 800-805
DOI: 10.1055/s-0037-1615751

Review Article

Schattauer GmbH

Antibodies to Phosphatidylethanolamine as the only Antiphospholipid Antibodies Found in Patients with Unexplained Thromboses

Marielle Sanmarco

¹Fédération Autoimmunité-Thrombose, Laboratoire d’Immunologie, Hôpital de La Conception, CHU

,

Marie-Christine Alessi

²Laboratoire d’Hématologie, Hôpital de La Timone, CHU

,

Jean Robert Harle

³Service de Médecine Interne, Hôpital de La Conception, CHU

,

Christophe Sapin

⁴Laboratoire de Santé Publique, Faculté de Médecine, CHU

,

Marie-Françoise Aillaud

²Laboratoire d’Hématologie, Hôpital de La Timone, CHU

,

Stéphanie Gentile

⁴Laboratoire de Santé Publique, Faculté de Médecine, CHU

,

Irène Juhan-Vague

²Laboratoire d’Hématologie, Hôpital de La Timone, CHU

,

Pierre-Jean Weiller

⁵Service de Médecine Interne, Hôpital de La Timone, CHU, Marseille, France

› Institutsangaben

Abstract

Summary

The objective of this study was to assess the interest of antiphosphatidylethanolamine antibodies (aPE) in unexplained thrombosis (UT) defined as thrombotic episode without any of the main autoimmune and hereditary thrombophilic defects. Results from 98 UT were compared to those of (I) 142 patients with thrombophilia: 67 antiphospholipid syndrome (APS) and 75 hereditary hemostatic defects (HHD); (II) 110 patients without thrombosis: 60 with systemic lupus erythematosus (SLE) and 50 with infectious diseases (ID). As compared to controls (100 blood donors), aPE prevalence was significantly higher in both autoimmune contexts (APS: 43%; SLE: 40%, p <0.0001) and among non-autoimmune pathologies, only in UT (18%, p = 0.001) conversely to HHD (8%) or ID (10%). aPE prevalence in UT was not statistically different from that found in Primary APS (32%, p = 0.076) but lower than in Secondary APS (65%, p <0.005). In UT, aPE were mainly of IgM isotype like in Primary APS and they were found alone whereas in SLE they were always associated with classical anti-phospholipid antibodies. No significant association was found between any isotype of aPE and a site of thrombosis in UT as well as in APS. In conclusion, this study demonstrates an increase of the prevalence of aPE in patients with unexplained thrombosis. Thus, aPE investigation appears to be of interest in UT and their persistent presence could define a biological variant of APS.

Keywords

Thrombosis - antiphospholipid syndrome - antiphospholipid antibodies - antiphosphatidylethanolamine antibodies

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Referenzen

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