Download PDF
Thromb Haemost 2001; 85(05): 890-895
DOI: 10.1055/s-0037-1615764
Review Article
Schattauer GmbH

Histidine-Proline-Rich Glycoprotein Binding to Platelets Mediated by Transition Metals

McDonald K. Horne III
1   Hematology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
,
Paula K. Merryman
1   Hematology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
,
Ann M. Cullinane
1   Hematology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
› Author Affiliations
Further Information

Publication History

Received 31 October 2000

Accepted after revision 20 December 2000

Publication Date:
11 December 2017 (online)

Also available at
    Permissions and Reprints

Summary

Histidine-proline-rich glycoprotein (HPRG) binds zinc, which in turn promotes HPRG binding to lymphocytes and monocytes. We examined the possibility that zinc and other transition metals also promote HPRG binding to platelets. Only non-specific, unsaturable association of HPRG with resting or activated platelets was observed in the absence of transition metals. However, nickel, cobalt, copper, cadmium, and zinc greatly increased HPRG association with the cells. In the presence of zinc, specific, saturable binding of HPRG to platelets was demonstrated. The cell binding capacity for HPRG could be increased by increasing the zinc saturation of HPRG from 10% to 30% as well as by activating the platelets with thrombin. Because platelets contain relatively high concentrations of secretable zinc, it is possible that significant amounts of HPRG bind to activated platelets at sites of blood clotting and that this has a physiologic function.

Keywords

Histidine-proline-rich glycoprotein - platelets - fibrinolysis - zinc
 

  • References

  • 1 Heimburger N, Haupt H, Kranz T, Bauder S. Humanserumproteine mit hoher Affinität zu Carboxymethylcellulose, II. Z Physiol Chem 1972; 353: 1133-40.
    CrossrefPubMedGoogle Scholar
  • 2 Lijnen HR, Hoylaerts M, Collen D. Isolation and characterization of a human plasma protein with affinity for the lysine binding sites in plasminogen. J Biol Chem 1980; 255: 10214-22.
    PubMedGoogle Scholar
  • 3 Koide T, Foster D, Yoshitake S, Davie EW. Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA. Biochemistry 1986; 25: 2220-5.
    CrossrefPubMedGoogle Scholar
  • 4 Gorgani NN, Parish CR, Smith SBE, Altin JG. Histidine-rich glycoprotein binds to human IgG and C1q and inhibits the formation of insoluble immune complexes. Biochemistry 1997; 36: 6653-62.
    CrossrefPubMedGoogle Scholar
  • 5 Morgan WT. Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands. Biochim Biophys Acta 1978; 533: 319-33.
    PubMedGoogle Scholar
  • 6 Borza D-B, Morgan WT. Histidine-proline-rich glycoprotein as a plasma pH sensor. J Biol Chem 1998; 273: 5493-9.
    CrossrefPubMedGoogle Scholar
  • 7 Morgan WT. Interactions of the histidine-rich glycoprotein of serum with metals. Biochemistry 1981; 20: 1054-61.
    CrossrefPubMedGoogle Scholar
  • 8 Olsen HM, Parish CR, Altin JG. Histidine-rich glycoprotein binding to T-cell lines and its effects on T-cell substratum adhesion is strongly potentiated by zinc. Immunology 1996; 88: 198-206.
    CrossrefPubMedGoogle Scholar
  • 9 Gorgani NN, Altin JG, Parish CR. Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes. International Immunology 1999; 11: 1275-82.
    CrossrefPubMedGoogle Scholar
  • 10 Lerch PG, Nydegger UE, Kuyas C, Haeberli A. Histidine-rich glycoprotein binding to activated human platelets. Br J Haematol 1988; 70: 219-24.
    CrossrefPubMedGoogle Scholar
  • 11 Cunningham BC, Bass S, Fuh G, Wells JA. Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science 1990; 250: 1709-12.
    CrossrefPubMedGoogle Scholar
  • 12 Rojkjaer R, Hasan AAK, Motta G, Schousboe I, Schmaier AH. Factor XII does not initiate prekallikrein activation on endothelial cells. Thromb Haemost 1998; 80: 74-81.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Gorodetsky R, Mou X, Blankenfeld A, Max G. Platelet multielemental composition, lability and subcellular localization. Am J Hematol 1993; 42: 278-83.
    CrossrefPubMedGoogle Scholar
  • 14 Aktulga A, Ulutin ON. Normal Human Platelet Zinc Content and Its Release. In: Platelets: Recent Advances in Basic Research and Clinical Aspects. Ulutin ON, Jones JV. eds. Amsterdam: Excerpta Medica; 1974: 185-91.
    Google Scholar
  • 15 General Clinical Tests In: Clinical Guide to Laboratory Tests. 3rd Ed. Tietz NW. ed. Philadelphia: W. W. Saunders Co; 1995: 2-760.
    Google Scholar
  • 16 Goad KE, Horne MK, Gralnick HR. Pentosan-induced thrombocytopenia: support for an immune complex mechanism. Brit J Haematol 1994; 88: 803-8.
    CrossrefPubMedGoogle Scholar
  • 17 Corash L, Tan H, Gralnick HR. Heterogeneity of whole blood platelet populations. I. Relationship between buoyant density, cell volume, and ultrastructure. Blood 1977; 49: 71-87.
    PubMedGoogle Scholar
  • 18 Miles LA, Plow EF. Binding and activation of plasminogen on the platelet surface. J Biol Chem 1985; 260: 4303-11.
    PubMedGoogle Scholar
  • 19 Agarwal RP, Perrin DD. Stability constants of complexes of copper (II) and zinc (II) ions with histidylhistidine. J Chem Soc Dalton Trans 1976; 1: 89-92.
    PubMedGoogle Scholar
  • 20 Scheinberg IH, Morell AG. Exchange of ceruloplasmin copper with ionic Cu64 with reference to Wilson’s disease. J Clin Invest 1957; 36: 1193-201.
    CrossrefPubMedGoogle Scholar
  • 21 Meloni FJ, Schmaier AH. Low molecular weight kininogen binds to platelets to modulate thrombin-induced platelet activation. J Biol Chem 1991; 266: 6786-94.
    PubMedGoogle Scholar
  • 22 Foote JW, Delves HT. Albumin bound and α2-macroglobulin bound zinc concentrations in the sera of healthy adults. J Clin Pathol 1984; 37: 1050-4.
    CrossrefPubMedGoogle Scholar
  • 23 Bax CMR, Bloxam DL. Human fetal endothelial cells acquire zinc (II) from both the protein bound and nonprotein bound pools in serum. Biological Trace Element Research 1997; 56: 255-71.
    CrossrefPubMedGoogle Scholar
  • 24 Marguerie GA, Edgington TS, Plow EF. Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. J Biol Chem 1980; 255: 154-61.
    PubMedGoogle Scholar
  • 25 Borza D-B, Tatum FM, Morgan WT. Domain structure and conformation of histidine-proline-rich glycoprotein. Biochemistry 1996; 35: 1925-34.
    CrossrefPubMedGoogle Scholar
  • 26 Borza D-B, Morgan WT. Acceleration of plasminogen activation by tissue plasminogen activator on surface-bound hisitidine-proline-rich glyco-protein. J Biol Chem 1997; 272: 5718-26.
    CrossrefPubMedGoogle Scholar
  • 27 Horne MK, Merryman P, Cullinane A. Histidine-rich glycoprotein binding to platelets depends upon plasminogen or certain divalent cations. Thromb Haemost. 1999 Suppl: 322 (Abstr no 1017).
    PubMedGoogle Scholar