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Thromb Haemost 1999; 82(02): 377-384
DOI: 10.1055/s-0037-1615856
Research Article
Schattauer GmbH

Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation

Atsushi Oda
1   Hokkaido Red Cross Blood Center, Keio University, Tokyo
,
Yoshitaka Miyakawa
2   Division of Hematology, Department of Internal Medicine, Keio University, Tokyo
,
Brian J. Druker
5   Division of Hematology and Medical Oncology, Oregon Health, OR, USA
,
Katsutoshi Ozaki
2   Division of Hematology, Department of Internal Medicine, Keio University, Tokyo
,
Hideya Ohashi
4   Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN
,
Takashi Kato
4   Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN
,
Hiroshi Miyazaki
4   Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN
,
Makoto Handa
5   Division of Hematology and Medical Oncology, Oregon Health, OR, USA
,
Kenji Ikebuchi
1   Hokkaido Red Cross Blood Center, Keio University, Tokyo
,
Yasuo Ikeda
2   Division of Hematology, Department of Internal Medicine, Keio University, Tokyo
› Author Affiliations
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Publication History

Publication Date:
09 December 2017 (online)

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Introduction

The presence of thrombopoietin, a humoral regulator of megakaryopoiesis and thrombopoiesis, had been suggested for years,1 however, some investigators were skeptical about the existence of such a factor. Modern studies of thrombopoietin begin with the cloning of c-mpl (the cellular counterpart of the v-mpl oncogene) and its cognate ligand genes. Following the cloning of the c-mpl proto-oncogene,2 Methia et al3 found that, in the presence of oligonucleotides antisense to the gene, CD34+ cells developed into megakaryocytic precursors less efficiently. As the development into other lineage was nearly intact, it was reasonably argued that the c-mpl protein may be the receptor for a thrombopoietin-like factor.3 This study inspired numerous investigations, which culminated in the cloning of the thrombopoietin gene in 1994.1, 4-8

 

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