Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation

Atsushi Oda; Yoshitaka Miyakawa; Brian J. Druker; Katsutoshi Ozaki; Hideya Ohashi; Takashi Kato; Hiroshi Miyazaki; Makoto Handa; Kenji Ikebuchi; Yasuo Ikeda

doi:10.1055/s-0037-1615856

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1999; 82(02): 377-384
DOI: 10.1055/s-0037-1615856

Research Article

Schattauer GmbH

Thrombopoietin-Induced Signal Transduction and Potentiation of Platelet Activation

Atsushi Oda

¹Hokkaido Red Cross Blood Center, Keio University, Tokyo

,

Yoshitaka Miyakawa

²Division of Hematology, Department of Internal Medicine, Keio University, Tokyo

,

Brian J. Druker

⁵Division of Hematology and Medical Oncology, Oregon Health, OR, USA

,

Katsutoshi Ozaki

²Division of Hematology, Department of Internal Medicine, Keio University, Tokyo

,

Hideya Ohashi

⁴Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN

,

Takashi Kato

⁴Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN

,

Hiroshi Miyazaki

⁴Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, JAPAN

,

Makoto Handa

⁵Division of Hematology and Medical Oncology, Oregon Health, OR, USA

,

Kenji Ikebuchi

¹Hokkaido Red Cross Blood Center, Keio University, Tokyo

,

Yasuo Ikeda

²Division of Hematology, Department of Internal Medicine, Keio University, Tokyo

› Author Affiliations

Abstract

Introduction

The presence of thrombopoietin, a humoral regulator of megakaryopoiesis and thrombopoiesis, had been suggested for years,¹ however, some investigators were skeptical about the existence of such a factor. Modern studies of thrombopoietin begin with the cloning of c-mpl (the cellular counterpart of the v-mpl oncogene) and its cognate ligand genes. Following the cloning of the c-mpl proto-oncogene,² Methia et al³ found that, in the presence of oligonucleotides antisense to the gene, CD34+ cells developed into megakaryocytic precursors less efficiently. As the development into other lineage was nearly intact, it was reasonably argued that the c-mpl protein may be the receptor for a thrombopoietin-like factor.³ This study inspired numerous investigations, which culminated in the cloning of the thrombopoietin gene in 1994.^{1, 4-8}

Full Text

References

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