The TF:VIIa Complex: Clinical Significance, Structure-function Relationships and Its Role in Signaling and Metastasis

William Konigsberg; Daniel Kirchhofer; Markus A. Riederer; Yale Nemerson

doi:10.1055/s-0037-1616129

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(03): 757-771
DOI: 10.1055/s-0037-1616129

Review Articles

Schattauer GmbH

The TF:VIIa Complex: Clinical Significance, Structure-function Relationships and Its Role in Signaling and Metastasis

William Konigsberg

¹The Department of Molecular Biophysics and Biochemistry, Yale University, New Haven CT, USA

,

Daniel Kirchhofer

²Department of Cardiovascular Research, Genentech Inc., South San Francisco, CA, USA

,

Markus A. Riederer

³Preclinical Research Department, F. Hoffmann-LaRoche Ltd., Basel, Switzerland

,

Yale Nemerson

⁴Division of Thrombosis Research, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA

› Author Affiliations

Abstract

Summary

In healthy humans, blood vessel-tissue factor is found primarily in the adventitia and thus physically separated from coagulation factors, which mainly circulate in an inactive form. Following injury, TF is exposed to blood and initiates the coagulation cascade. The resulting fibrin formation is an essential part for the initial repair of vessel damage to minimize blood-loss (reviewed by (1-4). Therefore, TF may be considered to form a hemostatic sheath around blood vessels essential for hemostasis and appears to be essential for life inasmuch as no TF deficiency has been reported and TF knockout mice do not survive beyond the perinatal period.

Full Text

References

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