Inverse correlation between phenylacetate hydrolase activity of the serum PON1 protein and homocysteinemia in humans

Thromb Haemost 2005; 93(01): 182-183
DOI: 10.1055/s-0037-1616165

Letters to the Editor

Schattauer GmbH

Nathalie Janel

²EA 3508, Université Paris 7, Paris, France

,

Karine Robert

²EA 3508, Université Paris 7, Paris, France

,

Karine Demuth

³Service de Biochimie, Hopital Europeen Georges Pompidou, Paris, France

,

Cédric Gouédard

¹INSERM UMR S-490, Université Paris V, Paris, France

,

Robert Barouki

¹INSERM UMR S-490, Université Paris V, Paris, France

³Service de Biochimie, Hopital Europeen Georges Pompidou, Paris, France

,

Jean François Chassé

¹INSERM UMR S-490, Université Paris V, Paris, France

³Service de Biochimie, Hopital Europeen Georges Pompidou, Paris, France

References
1 Glowacki R, Jakubowski H. Cross-talk between CYS-34 and lysine residues in human serum albumin revealed by N-homocysteinylation. J Biol Chem 2004; 279: 10864-71.
2 Jakubowski H, Ambrosius WT, Pratt JH. Genetic determinants of homocysteine thiolactonase activity in humans: implications for atherosclerosis. FEBS Lett 2001; 491: 35-9.
3 Voetsch B. Loscalzo. Genetic determinants of the arterial thrombosis. Arterioscler Thromb Vasc Biol 2004; 24: 216-29.
4 Jakubowski H. Calcium-dependant human serum homocysteine thiolactone hydrolase. J Biol Chem 2000; 275: 3957-62.
5 Robert K, Chassé JF, Santiard-Baron D. et al Altered gene expression in liver from a murine model of hyperhomocysteinemia. J Biol Chem 2003; 278: 31504-11.
6 Janel N, Robert K, Chabert C. et al Mouse liver paraoxonase- 1 gene expression is downregulated in hyperhomocysteinemia. Thromb Haemost 2004; 92: 221-2.
7 Jarvik GP, Hatsukami TS, Carlson C. et al Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. Arterioscler Thromb Vasc Biol 2003; 23: 1465-71.
8 Jakubowski H. The determination of homocysteine- thiolactone in biological samples. Anal Biochem 2002; 308: 112-9.