Extracellular Proteolysis and Angiogenesis

Michael S. Pepper

doi:10.1055/s-0037-1616232

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(01): 346-355
DOI: 10.1055/s-0037-1616232

Research Article

Schattauer GmbH

Extracellular Proteolysis and Angiogenesis

Michael S. Pepper

¹Department of Morphology, University Medical Center, Geneva, Switzerland

› Author Affiliations

Abstract

Summary

Extracellular proteolysis is an absolute requirement for new blood vessel formation, a process known as angiogenesis. This review will examine the role of the matrix metalloproteinase and plasminogen activator/plasmin systems during angiogenesis. Extracellular proteolysis has also been implicated in the generation of molecules with angioregulatory activity. These include, but are not limited to, angiostatin and endostatin. However, despite an abundance of data on their bioactivity, the molecular mechanisms by which these molecules achieve their effects are unknown. Anti-proteolysis, particularly in the context of angiogenesis, has become a key target in therapeutic strategies aimed at inhibiting tumor growth and other diseases associated with neovascularization.

Key words

Matrix - metalloproteinase - plasminogen - angiostatin - endostatin

Full Text

References

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