Foetal Growth Restriction in Children with Prothrombotic Risk Factors

Rüdiger von Kries; Ralf Junker; Doris Oberle; Andrea Kosch; Ulrike Nowak-Göttl

doi:10.1055/s-0037-1616526

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(04): 1012-2001
DOI: 10.1055/s-0037-1616526

Special Article

Schattauer GmbH

Foetal Growth Restriction in Children with Prothrombotic Risk Factors

Rüdiger von Kries

¹Institute for Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians-University Munich, Germany

,

Ralf Junker

²Department of Clinical Chemistry and Laboratory Medicine, and Department of Arteriosclerosis Research, University of Münster, Germany

,

Doris Oberle

¹Institute for Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians-University Munich, Germany

,

Andrea Kosch

³Department of Paediatric Haematology/Oncology, University of Münster, Germany

,

Ulrike Nowak-Göttl

³Department of Paediatric Haematology/Oncology, University of Münster, Germany

› Author Affiliations

Abstract

Summary

Placental infarction is frequently observed in low birth weight children. To evaluate whether low birth weight in healthy term neonates is associated with foetal inherited prothrombotic risk factors this retrospective study was conducted. Outcome measures were “birth weight in the lowest quartile” and “birth weight in the lowest decile” in singletons with a gestational age of ≥37 weeks.

The analyses were based on 375 Caucasian children screened at the Münster childhood thrombophilia centre with complete data for all prothrombotic risk factors (factor V G1691A, prothrombin G20210A, elevated lipoprotein (a), protein C-, protein S-, antithrombin-deficiency). The proportion of children in the lowest birth weight quartile increased from 23.7% to 30.5% to 48.0% for children with no, only single heterozygous and multiple or homozygous defects respectively. The respective adjusted odds ratios (95% confidence intervals) of thrombophilia for birth weight in the lowest quartile (lowest decile) were 1.53 (0.76-3.08) in carriers of one prothrombotic risk factor and 4.01 (1.48-10.84) in subjects carrying multiple or homozygous defects. We identified foetal thrombophilia as an additional cause of low birth weight.

Keywords

Foetal growth restriction - factor V G1691A - prothrombin G20210A - lipoprotein (a) - protein C - protein S - antithrombin

Full Text

References

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