Download PDF
Thromb Haemost 2001; 86(04): 1133-1134
DOI: 10.1055/s-0037-1616557
Letters to the Editor
Schattauer GmbH

On the Role of EPR-1 or an EPR-1-like Molecule in Regulating Factor Xa Incorporation into Platelet Prothrombinase

Beth A. Bouchard
1   Departments of Biochemistry, College of Medicine, Burlington, VT, USA
,
Jay R. Silveira
1   Departments of Biochemistry, College of Medicine, Burlington, VT, USA
,
Paula B. Tracy
1   Departments of Biochemistry, College of Medicine, Burlington, VT, USA
2   Medicine, University of Vermont, College of Medicine, Burlington, VT, USA
› Author Affiliations
Further Information

Publication History

Received 21 May 2001

Accepted 21 May 2001

Publication Date:
09 December 2017 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Briedé JJ, Heemskerk JWM, van’t Veer C, Hemker HC, Lindhout T. Contribution of platelet-derived factor Va to thrombin generation on immobilized collagen- and fibrinogen-adherent platelets. Thromb Haemost 2001; 85: 509-13.
    Thieme ConnectPubMedSearch in Google Scholar
  • 2 Altieri DC, Edgington TS. Sequential receptor cascade for coagulation proteins on monocytes. Constitutive biosynthesis and functional prothrombinase activity of a membrane form of factor V/Va. J Biol Chem 1989; 264: 2969-72.
    PubMedSearch in Google Scholar
  • 3 Altieri DC, Edgington TS. Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa. J Immunol 1990; 145: 246-53.
    PubMedSearch in Google Scholar
  • 4 Nicholson AC, Nachman RL, Altieri DC, Summers BD, Ruf W, Edgington TS, Hajjar DP. Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa. J Biol Chem 1996; 271: 28407-13.
    CrossrefPubMedSearch in Google Scholar
  • 5 Bouchard BA, Shatos MA, Tracy PB. Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation. Arterioscler Thromb Vasc Biol 1997; 17: 1-9.
    CrossrefPubMedSearch in Google Scholar
  • 6 Bouchard BA, Catcher CS, Thrash BR, Adida C, Tracy PB. Effector cell pro-tease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation. J Biol Chem 1997; 272: 9244-51.
    CrossrefPubMedSearch in Google Scholar
  • 7 Ambrosini G, Altieri DC. Molecular dissection of effector cell protease receptor-1 recognition of factor Xa. Assignment of critical residues involved in antibody reactivity and ligand binding. J Biol Chem 1996; 271: 1243-8.
    CrossrefPubMedSearch in Google Scholar
  • 8 Larson PJ, Camire RM, Wong D, Fasano NC, Monroe DM, Tracy PB, High KA. Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles. Biochemistry 1998; 37: 5029-38.
    CrossrefPubMedSearch in Google Scholar
  • 9 Rudolph AE, Porche-Sorbet R, Miletich JP. Substitution of asparagine for arginine 347 of recombinant factor Xa markedly reduces factor Va binding. Biochemistry 2000; 39: 2861-7.
    CrossrefPubMedSearch in Google Scholar