High prevalence of 5G allele in Amerindian tribes and Mestizos from Mexico at 4G/5G PAI-1 gene promoter polymorphism

Ismael Nuño-Arana; Luis Antonio Páez-Riberos; Lucila Sando-val-Ramírez; José Francisco Muñoz-Valle; Doris Pinto-Escalante; José Miguel Ceballos-Quintal; Héctor Rangel-Villalobos

doi:10.1055/s-0037-1616576

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2005; 93(05): 1005-1007
DOI: 10.1055/s-0037-1616576

Letters to the Editor

Schattauer GmbH

High prevalence of 5G allele in Amerindian tribes and Mestizos from Mexico at 4G/5G PAI-1 gene promoter polymorphism

Ismael Nuño-Arana

¹Laboratorio de Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán Jalisco, Mexico

²Programa de Doctorado en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico

,

Luis Antonio Páez-Riberos

¹Laboratorio de Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán Jalisco, Mexico

²Programa de Doctorado en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico

,

Lucila Sando-val-Ramírez

³División de Genética, Centro de Investigación Biomédica de Occidente (CIBO-IMSS), Guadalajara, Jalisco, Mexico

,

José Francisco Muñoz-Valle

⁴Laboratorio de Inmunología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico

,

Doris Pinto-Escalante

⁵Laboratorio de Genética, Centro de Investigaciones Regionales Hi-deyo Noguchi, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico

,

José Miguel Ceballos-Quintal

⁵Laboratorio de Genética, Centro de Investigaciones Regionales Hi-deyo Noguchi, Universidad Autónoma de Yucatán (UADY), Mérida, Yucatán, Mexico

,

Héctor Rangel-Villalobos

¹Laboratorio de Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán Jalisco, Mexico

²Programa de Doctorado en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico

References
1 Kohler HP, Grant PJ. Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med 2000; 342: 1792-801.
2 Boekholdt SM, Bijsterveld NR, Moons AH. et al. Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction: a systematic review. Circulation 2001; 104: 3063-8.
3 Iacoviello L, Burzotta F, Di Castelnuovo A. et al. The 4G/5G polymorphism of PAI-1 promoter gene and the risk of myocardial infarction: a meta-analysis. Thromb Haemost 1998; 80: 1029-30.
4 Ruiz-Quezada S, Vázquez-Del Mercado M, Parra-Rojas I. et al. Genotype and allele frequency of PAI-1 promoter polymorphism in healthy subjects from the west of Mexico. Association with biochemical and hematological parameters. Ann Genet 2004; 47: 155-62.
5 Scheffler L. Los Indígenas Mexicanos. Editorial Panorama, México D.F. 1999
6 Margaglione M, Grandone E, Cappucci G. et al. An alternative method for PAI-1 promoter polymorphism (4G/5G) typing. Thromb Haemost 1997; 77: 605-6.
7 Miller MP. Tools for population genetic analysis (TFPGA) version 1.3. Department of Biological Sciences-Box 5640, Northern Arizona University. http://herb.bio.nau.ed/miller 1997
8 Gorodesky C, Alaez C, Vazquez-García MN. et al. The genetic structure of Mexican mestizos of different locations: Tracking back their origins through MHC genes, blood group systems, and microsatellites. Hum Immunol 2001; 62: 979-91.
9 Crawford MH. The origin of native Americans: Evidence from anthropological genetics. 1998. Cambridge: University Press;
10 Hispanics/Latinos and Cardivascular diseases-statistics. American Heart Asociation. 2004 americanheart.org
11 Pegoraro RJ, Hira B, Rom L. et al. Plasminogen activator inhibitor type 1 (PAI1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in Black South Africans with pre-eclampsia. Acta Obstet Gynecol Scand 2003; 82: 313-7.
12 Nagi DK, McCormack LJ, Mohamed-Ali V. et al. Diabetic retinopathy, promoter (4G/5G) polymorphism of PAI-1 gene, and PAI-1 activity in Pima Indians with type 2 diabetes. Diabetes Care 1997; 20: 1304-9.
13 Byberg L, Smedman A, Vessby B. et al. Plasminogen activator inhibitor-1 and relations to fatty acid composition in the diet and in serum cholesterol esters. Arterioscler Thromb Vasc Biol, 2001; 21: 2086-92.
14 Yamamoto K, Takeshita K, Shimokawa T. et al. Plasminogen activator inhibitor-1 is a major stressregulated gene: implications for stress-induced thrombosis in aged individuals. Proc Natl Acad Sci U S A 2002; 99: 890-5.
15 Sartori MT, Wiman B, Vettore S. et al. 4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis. Thromb Haemost 1998; 80: 956-60.