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Thromb Haemost 2001; 86(06): 1400-1408
DOI: 10.1055/s-0037-1616742
Review Article
Schattauer GmbH

Complexes between Activated Protein C and Protein C Inhibitor Measured with a New Method

Comparison of Performance with other Markers of Hypercoagulability in the Diagnosis of Deep Vein Thrombosis
Karin Strandberg
1   Department of Clinical Chemistry, University Hospital, Malmö, Lund University, Malmö, Sweden
,
Jan Astermark
2   Department of Coagulation Disorders, University Hospital, Malmö, Lund University, Malmö, Sweden
,
Ola Björgell
3   Department of Diagnostic Radiology, University Hospital, Malmö, Lund University, Malmö, Sweden
,
Charlotte Becker
1   Department of Clinical Chemistry, University Hospital, Malmö, Lund University, Malmö, Sweden
,
Paul E. Nilsson
3   Department of Diagnostic Radiology, University Hospital, Malmö, Lund University, Malmö, Sweden
,
Johan Stenflo
1   Department of Clinical Chemistry, University Hospital, Malmö, Lund University, Malmö, Sweden
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 10. Mai 2001

Accepted after revision 06. August 2001

Publikationsdatum:
12. Dezember 2017 (online)

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Summary

A first clinical evaluation has been made of the performance of a newly devised immunofluorometric assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI). The method was compared with testing for other markers of hypercoagulability in a case-control study comprising 123 patients with clinical suspicion of deep vein thrombosis (DVT). The diagnosis was confirmed by ascending phlebography, and the thrombotic burden estimated with a newly developed scoring system. Receiver operating characteristics (ROC) curves calculated to demonstrate the discriminatory capacity of the methods, showed the area under the curves (AUCs) to be similar for the APC-PCI and D-dimer methods. However, in contrast to the D-dimer method, the APC-PCI method measures a well-defined analyte, a prerequisite for reliable comparisons of future clinical studies. The APC-PCI method appears to be particularly useful as a marker for detection of recently developed proximal thrombi.

Keywords

APC-PCI complex - immunofluorometric assay - deep vein thrombosis - case-control study - hypercoagulability markers
 

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