Prevalence of Factor V Leiden and Prothrombin 20210A Mutations in Indigenous Australians

J. A. Bennett; L. J. Palmer; A. W. Musk; W. N. Erber

doi:10.1055/s-0037-1616775

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2001; 86(06): 1592-1593
DOI: 10.1055/s-0037-1616775

Letters to the Editor

Schattauer GmbH

Prevalence of Factor V Leiden and Prothrombin 20210A Mutations in Indigenous Australians

J. A. Bennett

¹Haematology Department, Western Australian Centre for Pathology and Medical Research (PathCentre), Australia

,

L. J. Palmer

²Channing Laboratory, Brigham and Women‘s Hospital and Harvard Medical School, Boston, MA, USA

,

A. W. Musk

³Departments of Medicine and Public Health, University of Western Australia

⁴Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, Western Australia

,

W. N. Erber

¹Haematology Department, Western Australian Centre for Pathology and Medical Research (PathCentre), Australia

⁵Department of Pathology, University of Western Australia

› Author Affiliations

Abstract

Full Text

References

References
1 Dahlbäck B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 1993; 90: 1004-8.
2 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
3 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
4 Pepe G, Rickards O, Vanegas OC, Brunelli T, Gori AM, Giusti B, Attanasio M, Prisco D, Gensini GF, Abbate R. Prevalence of factor V Leiden mutation in non-European populations. Thromb Haemost 1997; 77: 329-31.
5 Rosendaal FR, Doggen CJM, Zivelin A, Arruda VR, Arach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
6 Franco RF, Santos SEB, Elion J, Tavella MH, Zago MA. Prevalence of the G20210A polymorphism in the 3′-untranslated region of the prothrombin gene in different human populations. Acta Haematol 1998; 100: 9-12.
7 Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: a laboratory manual. 2nd edn. 1984. Cold Spring Harbour Laboratory Press New York.:
8 Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 1994; 369: 64-7.
9 Van Bockxmeer FM, Baker RJ, Taylor RR. Premature ischaemic heart disease and the gene for cogulation factor V. Nat Med (letter) 1995; 1: 85.
10 Chan DK, Hu G, Tao H, Owens D, Vun CM, Woo J, Chong BH. A comparison of the polymorphism in the 3′-untranslated region of the prothrombin gene between Chinese and Caucasians in Australia. Br J Haematol 2000; 111: 1253-5.