Inflammation, innate immunity and blood coagulation

Summary

Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure.

Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade.

Zusammenfassung

Entzündung fördert arterielle, venöse und mikrovaskuläre Thrombosen. Eine chronische Entzündung trägt zu arteriellen Thrombosekomplikationen bei, während eine akute Entzündung venöse und mikrovaskuläre Thrombosen fördert. Mechanistisch gesehen moduliert eine Entzündung die Thromboseantwort durch Hochregulierung von Prokoagulanzien, Herunterregulierung von Antikoagulanzien und Unterdrückung der Fibrinolyse. Die Entzündungsreaktion kann auch zur Apoptose oder Nekrose von Zellen führen. Von abge -storbenen Zellen freigesetzte Produkte, vor allem Histone, fördern zusätzlich Entzündung, Gewebeuntergang und Organversagen. Eine Hemmung der histonvermittelten Zyto -toxizität stellt anscheinend einen neuen Schutzmechanismus gegen diese tödliche Kaskade dar.

Keywords

Thrombosis - inflammation - sepsis - multiorgan failure

Schlüsselwörter

Thrombose - Entzündung - Sepsis - Multiorganversagen

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