Nicht-bakterielle Osteitiden bei Kindern, Jugendlichen und Erwachsenen

Annette Jansson; Michael Borte; Hermann J. Girschick; Frank Dressler; Bernd H. Belohradsky

doi:10.1055/s-0037-1617920

Kinder- und Jugendmedizin, Table of Contents

Kinder- und Jugendmedizin 2006; 6(05): 299-303
DOI: 10.1055/s-0037-1617920

Kinderrheumatologie

Schattauer GmbH

Nicht-bakterielle Osteitiden bei Kindern, Jugendlichen und Erwachsenen

Klinik, Diagnostik, TherapieNon-bacterial osteitis in children, adolescents and adults

Annette Jansson

¹Kinderklinik und Kinderpoliklinik, Dr. von Haunersches Kinderspital der LMU München (Direktor: Prof. Dr. med. D. Reinhardt)

,

Michael Borte

²Klinik für Kinder- und Jugendmedizin, Städtisches Klinikum „St. Georg“ Leipzig (Chefarzt: Prof. Dr. med. Th. Richter)

,

Hermann J. Girschick

³Kinderklinik des Universitätsklinikums Würzburg (Direktor: Prof. Dr. med. Christian P. Speer)

,

Frank Dressler

⁴Kinderklinik, Medizinische Hochschule Hannover (Direktorin: Prof. Dr. med. Gesine Hansen)

,

Bernd H. Belohradsky

¹Kinderklinik und Kinderpoliklinik, Dr. von Haunersches Kinderspital der LMU München (Direktor: Prof. Dr. med. D. Reinhardt)

› Author Affiliations

Abstract

Zusammenfassung

Die nicht-bakterielle Osteitis (NBO) ist eine autoinflammatorische Erkrankung mit ungeklärter Ätiologie und Pathogenese. Gebräuchliche Synonyme sind CRMO (chronisch rekurrierende multifokale Osteomyelitis) und SAPHO-Syndrom (Synovitis, Akne, Pustulosis, Hyperostosis, Osteitis). Die NBO stellt eine wichtige Differenzialdiagnose der bakteriellen Osteomyelitis dar und wird dem rheumatischen Formenkreis zugeordnet. Sie kann sich sowohl im Kindesals auch im Erwachsenenalter manifestieren und einen akuten oder einen chronischen Verlauf nehmen. Eine frühzeitige Diagnosestellung bewahrt den Patienten vor langwierigen, unnötigen antibiotischen Behandlungen und invasiven Eingriffen. Nach aktuellem Wissensstand sind nichtsteroidale Antiphlogistika die Therapie der Wahl.

Summary

Non-bacterial osteitis (NBO) is an autoinflammatory disease of unknown origin and pathogenesis. In the literature NBO is usual known as CRMO (chronic recurrent multifocal osteomyelitis) and SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis). The disorder should be considered as an important differential diagnosis of bacterial osteomyelitis. NBO is thought to belong to the rheumatic disorders and can occur at any age. Its clinical course can be either acute or chronic. Early diagnosis prevents patients from unnecessary long lasting antibiotic therapies and invasive procedures. According to current knowledge NSAIDs are the treatment of choice.

Schlüsselwörter

Nicht-bakterielle Osteitis (NBO) - chronisch rekurrierende multifokale Osteomyelitis (CRMO) - SAPHO-Syndrom

Keywords

Non-bacterial osteitis (NBO) - chronic recurrent multifocal osteomyelitis (CRMO) - SAPHO syndrome

Full Text

References

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