Schlaf bei allergischer Rhinitis & Asthma bronchiale

Die allergische Rhinitis und das Asthma bronchiale sind chronische Erkrankungen mit einer hohen Prävalenz. Veränderungen der Atmung und der Lungen - funktion im Schlaf können beim Asthma bronchiale zu einer Verstärkung der bronchialen Obstruktion führen. Bei beiden Erkrankungen besteht zudem eine erhöhte Prävalenz schlafbezogener Atmungsstörungen. Dieser Artikel versucht die komplexen Zusammenhänge zwischen den Erkrankungen und dem Schlaf aus pathophysiologischer Sicht zu beleuchten und Konsequenzen für Diagnostik und Therapie aufzuzeigen.

• Literatur

• 1 Douglas NJ, White DP, Pickett CK. et al Respiration during sleep in normal man. Thorax 1982; 37: 840-844.
• 2 Dempsey JA, Veasey SC, Morgan BJ. et al Pathophysiology of sleep apnea. Physiol Rev 2010; 90: 47-112.
• 3 Douglas NJ, White DP, Weil JV. et al Hypercapnic ventilatory response in sleeping adults. Am Rev Respir Dis 1982; 126: 758-762.
• 4 Martin RJ, Banks-Schlegel S. Chronobiology of asthma. Am J Respir Crit Care Med 1998; 158: 1002-1007.
• 5 Colas C, Galera H, Anibarro B. et al Disease severity impairs sleep quality in allergic rhinitis (the SOMNIAAR study). Clin Exp Allergy 2012; 42: 1080-1087.
• 6 Léger D, Annesi-Maesano I, Carat F. et al Allergic rhinitis and its consequences on quality of sleep: an unexplored area. Arch Intern Med 2006; 166: 1744-1748.
• 7 Corey JP, Houser SM, Ng BA. Nasal congestion: a review of its etiology, evaluation, and treatment. Ear Nose Throat J 2000; 79: 690-693.
• 8 Marshall NS, Almqvist C, Grunstein RR. et al Predictors for snoring in children with rhinitis at Age 5. Pediatr Pulmonol 2007; 42: 584-591.
• 9 Hughes K, Glass C, Davies M. et al Efficacy of the topical nasal steroid budenoside on improving sleep and daytime somnolence in patients with perennial allergic rhinitis. Allergy 2003; 58: 380-385.
• 10 Craig TJ, Hanks CD, Fisher LH. How do topical nasal corticosteroids improve sleep and daytime somnolence in allergic rhinitis?. J Allergy Clin Immunol 2005; 116: 1264-1266.
• 11 Mastronarde JG, Wise RA, Shade DM. et al Sleep quality in asthma: results of a large prospective clinical trial. J Asthma 2008; 45: 183-189.
• 12 Janson C, De Backer W, Gislason T. et al Increased prevalence of sleep disturbances and daytime sleepiness in subjects with bronchial asthma: a population study of young adults in three European countries. Eur Respir J 1996; 9: 2132-2138.
• 13 Diette GB, Markson L, Skinner EA. et al Nocturnal asthma in children affects school attendance, school performance, and parents‵work attendance. Arch Pediatr Adolesc Med 2000; 154: 923-928.
• 14 Glovinsky PB, Yang C, Dubrovsky B. et al Nonpharmacologic strategies in the management of insomnia: Rationale and implementation. Sleep Med Clin 2008; 3: 189-204.
• 15 Bonnet R, Jorres R, Heitmann U. et al Circadian rhythm in airway responsiveness and airway tone in patients with mild asthma. J Appl Physiol 1991; 71: 1598-1605.
• 16 Mohiuddin AA, Martin RJ. Circadian basis of the late asthmatic response. Am Rev Respir Dis 1990; 142: 1153-1157.
• 17 Bellia V, Bonanno A, Cibella F. et al Urinary leukotriene E4 in the assessment of nocturnal asthma. J Allergy Clin Immunol 1996; 97: 735-741.
• 18 Kraft M, Hamid Q, Chrouos GP. et al Decreased steroid responsiveness at night in nocturnal asthma: Is the macrophage responsible?. Am J Respir Crit Care Med 2001; 163: 1219-1225.
• 19 Irvin CG, Pak J, Martin RJ. Airway parenchyma uncoupling in nocturnal asthma. Am J Respir Crit Care Med 2000; 161: 50-56.
• 20 Koinis-Mitchell D, Craig T, Esteban CA. et al Sleep and allergic disease: a summary of the literature and future directions for research. J Allergy Clin Immunol 2012; 130: 1275-1281.
• 21 Lafond C, Sériès F, Lemière C. Impact of CPAP on asthmatic patients with obstructive sleep apnoea. Eur Respir J 2007; 29: 307-311.
• 22 Ahmed T, Marchette B. Hypoxia enhances non-specific bronchial reactivity. Am Rev Respir Dis 1985; 132: 839-844.
• 23 Valipour A, Makker HK, Hardy R. et al Symptomatic gastroesophageal reflux in subjects with a breathing sleep disorder. Chest 2002; 121: 1748-1753.
• 24 Boyd JH, Petrof BJ, Hamid Q. et al Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med 2004; 70: 541-546.
• 25 Lee YC, Kwak YG, Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanateinduced asthma. J Immunol 2002; 168: 595-600.
• 26 Shore SA, Schwartzman IN, Mellema MS. et al Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005; 115: 103-109.
• 27 Thomson CC, Clark S, Camargo Jr CA. Body mass index and asthma severity among adults presenting to the emergency department. Chest 2003; 124: 795-802.