Adipositas - Ursachen, Folgeerkrankungen, Therapie 2011; 05(03): 121-126
DOI: 10.1055/s-0037-1618744
Gestationsdiabetes
Schattauer GmbH

Diagnostik und Behandlung des Gestationsdiabetes entsprechend den aktuellsten Leitlinien

Diagnostic procedure and treatment of gestational diabetes according to the most recent guidelines
U. Schäfer-Graf
1   Berliner Diabeteszentrum für Schwangere, Klinik für Gynäkologie & Geburtshilfe, St. Joseph Krankenhaus
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
28. Dezember 2017 (online)

Zusammenfassung

Gestationsdiabetes (GDM) ist eine der häufigsten Schwangerschaftserkrankungen mit steigender Prävalenz – nicht zuletzt wegen der bedenklichen Zunahme von Adipositas unter jungen Frauen. GDM ist aber auch eine der Schwangerschaftskomplikationen, über die in den letzten Jahren am meisten diskutiert wurde – mit den größten Kontroversen insbesondere zur Frage der Diagnostik. Auch die Ansichten über die Intensität der Stoffwechselkontrolle, die Blutzuckerzielwerte und die Indikation zur Insulintherapie gingen weit auseinander, sehr zum Leidwesen der Behandler und der Schwangeren. Die letzten fünf Jahre erbrachten durch die Veröffentlichung bahnbrechender Studien einen großen Erkenntnisgewinn, der sich weltweit in neuen Empfehlungen zur Diagnostik und Therapie des GDM niederschlägt. So auch in Deutschland: eine interdisziplinäre Arbeitsgruppe der Diabetologen, Geburtmediziner und Neonatalogen hat in Anlehnung an diese internationalen Empfehlungen die seit 2001 gültigen Leitlinien überarbeitet. Der nachfolgende Artikel stellt die wichtigsten prakti schenAspekte für das diagnostische und therapeutische Vorgehen vor.

Summary

Gestational diabetes (GDM) is one of the most common disorders in pregnancy with increa -sing prevalence – partly due to the alarming increase of obesity in young women. However, GDM wasalso one pregnancy complication with the highest need for discussion in the last decade and there was a wide controversy particularly regarding the diagnostic procedure and criteria but as well regarding intensity of glucose control, glucose goal and when to start insulin therapy. A very difficult situation for care givers and patients. Finally, publications of epoch-making studies during the last five years provided data with high level of evidence and lead to new recommendations. These are going to be adopted worldwide to create uniform criteria for the diagnosis of GDM. Germany follows the line: an interdisciplinary expert team of diabetologists, perinatologists and neonatologists revised the German guidelines from 2001 according to the international proposal. The article presents the most relevant practical aspects regarding the recommended diagnostic and therapeutic procedure.

 
  • Literatur

  • 1 International Association of Diabetes and Pregancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care. 2010; 33: 676-682.
  • 2 Kautzky-Willer A. et al. Pronounced insulin resistance and inadequate beta-cell insulin secretion characterize lean gestational diabetes mellitus. Diabetes Care 1997; 20: 1717-1723.
  • 3 Xiang A. et al. Detailed Physiological Characterization of the Dvelopment of Type 2 Diabetes in Hispanic Women With Prior Gestational Diabetes Mellitus. Diabetes Care 2010; 59: 2625-2630.
  • 4 Kautzky-Willer A. et al. Decreased plasma adiponectin concentrations in women with gestational diabetes mellitus. Am J Obstet Gynecol 2004; 191: 2120-2124.
  • 5 Watanabe R. et al. Transcription factor 7-like 2 (TCF7L2) is associated with gestational diabetes mellitus and interacts with adiposity to alter insulin secretion in Mexican American. Diabetes 2007; 56: 1481-1485.
  • 6 American Diabetes Association : Standards of Medical Care in Diabetes—2011. Diabetes Care. 2011; 34 (01) S11-S61.
  • 7 Naylor C, Sermer M, Chen E, Farine D. Selective screening for gestational diabetes mellitus. Toronto Trihospital Gestational Diabetes Project Investigators. N Engl J Med 1997; 27: 1591-1596.
  • 8 Sermer M. et al. Impact of time since last meal on the gestational glucose challenge test. The Toronto Tri- Hospital Gestational Diabetes Project. Am J Obstet Gynecol 1994; 17: 607-616.
  • 9 Bühling KJ, Stein U, Dudenhausen JW. Evaluation des 50 gr-Glukose-Screningtest an 1416 Schwangeren. Geburtsh. u. Frauenheilk 1998; 58: 100-109.
  • 10 Meltzer S. et al. Gestational diabetes mellitus screening and diagnosis: a prospective randomised controlled trial comparing costs of one-step and two-step methods. BJOG 2010; 117: 407-415.
  • 11 Ryan E: Diagnosing Gestational Diabetes. Diabetologia. Jan 4. [Epub ahead of print], 2011
  • 12 Metzger B. et al. Hyperglycemia and adverse pregnancy outcomes. NEJM 2008; 358: 2061-2063.
  • 13 D´Orazio P. et al. the International Federation of Clinical Chemistry Scientific Division Working Group on Selective Electrodes and Point of Care Testing (IFCC-SD W-S: Approved IFCC Recommendation on Reporting Results for Blood Glucose (Abbreviated). Clin Chem 2005; 01: 1573-1576.
  • 14 Crowther C. et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcome. NEJM 2005; 352: 2477-2486.
  • 15 Landon M. et al. A multicenter, randomized trial of treatment for mild gestational diabetes. NEJM 2009; 361: 1339-1348.
  • 16 Horvath K. et al. Effects of treatment in women with gestational diabetes mellitus: systematic review and meta-analysis. BMJ 2010; 340: c1395 doi: 1310.1136/bmj.c1395.
  • 17 Major CA, Henry MJ, De Veciana M, Morgan MA. The effects of carbohydrate restriction in patients with diet-controlled gestational diabetes. Obstet Gynecol 1998; 91: 600-604.
  • 18 (IOM) IoM: Weight gain during pregnancy: Reexamining the guidelines. Washington D. Ed. The National Academies Press; 2009
  • 19 Kiel D. et al. Gestational weight gain and pregnancy putcomes in obese women: How much is enough?. Obstet Gynecol 2007; 110: 752-758.
  • 20 Crane J, White J, Murphy P, Burrage LDH. >The effect of gestational weight gain by body mass index on maternal and neonatal outcomes. J Obstet Gynaecol Can 2009; 31: 28-35.
  • 21 Bung P, Artal R, Khodiguian N, Kjos S. Exercise in gestational diabetes. An optional therapeutic approach?. Diabetes 1991; 40 (Suppl. 02) 182-185.
  • 22 Langer O, Yogev Y, Xenakis E, Brustman L. Overweight and obese in gestational diabetes: the impact on pregnancy outcome. Am J Obstet Gynecol 2005; 192: 1768-1776.
  • 23 Kessel S. et al. Gestational diabetes under clinical conditions in aspired normoglycemia: investigation for correlation of blood glucose daily profiles and fetometric ultrasound parameters. Z Geburtshilfe Neonatol 2007; 211: 185-1890.
  • 24 Schaefer-Graf U. et al. Amniotic fluid insulin levels and fetal abdominal circumference at time of amniocentesis in pregnancies with diabetes. Diabetic Med 2003; 20: 349-335.
  • 25 Kainer F, Weiss PAM, Hüttner U, Haas J. Ultrasound growth parameters in relation to levels of amniotic fluid insulin in women with diabetes type I. Early Hum Dev 1997; 49: 113-121.
  • 26 Kjos S, Schaefer-Graf U. Modified therapy for gestational diabetes using high-risk and low-risk fetal abdominal circumference growth to select srtrict versus relaxed matrenal glycemic target. Diabetes Care 2007; 30: S200-205.
  • 27 Kjos S, Schäfer-Graf UM. et al. A randomized controlled trial using glycemic plus fetal ultrasound parameters versus glycemic parameters to determine insulin therapy in gestational diabetes with fasting hyperglycemia. Diabetes Care 2001; 24: 1904-1910.
  • 28 Schaefer-Graf U. et al. A randomized trial evaluating a predominately fetal growth-based strategy to guide management of gestational diabetes in Caucasian women. Diabetes Care 2004; 27: 297-302.
  • 29 Bonomo M. et al. Flexible treatment of gestational diabetes modulated on ultrasound evaluation of intrauterine growth: a controlled randamized clinical trial. Diabetes Metab 2004; 30: 237-244.
  • 30 Buchanan TA. et al. Use of fetal ultrasound to select metabolic therapy for pregnancies complicated by mild gestational diabetes. Diabetes Care 1994; 17: 275-283.
  • 31 Weiss P, Scholz H, Haas J, Tamussino K. Effect of fetal hyperinsulinism on oral glucose tolerance test results in patients with gestational diabetes mellitus. Am J Obstet Gynecol 2001; 184 (03) 470-475.
  • 32 Rowan J, Hague W, Goa W. Investigators ftMT. Metformin versus Insulin for the treatment of Gestational Diabetes. NEJM 2008; 358: 2003-2015.
  • 33 Langer O, Conway D, Berkus M. A comparison of glyburide and insulin in women with gestational diabetes. NEJM 2000; 343: 1134-1138.